Seroatlas · Human Serome Atlas

KRT10-AS1

Uncharacterized protein KRT10-AS1

Also known as: TMM99_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N816
Gene: KRT10-AS1
Canonical length: 258 aa

OverviewNCBI Gene

No narrative summary is available for KRT10-AS1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

258 residues, UniProt reviewed canonical sequence.

>Q8N816|KRT10-AS1
     1  MVGILPLCCS GCVPSLCCSS YVPSVAPTAA HSVRVPHSAG HCGQRVLACS LPQVFLKPWI
    61  FVEHFSSWLS LELFSFLRYL GTLLCACGHR LREGLLLPCL LGVGSWLLFN NWTGGSWFSL
   121  HLQQVSLSQG SHVAAFLPEA IGPGVPVPVS GESTSAQQSH AGWQLSAEAD ACPSVLYSEV
   181  LEWNKNINTY TSFHDFCLIL GIFLFCFVLA VIGLPYIKPG LSLSVALLWQ SLILLSSLVQ
   241  QDSQVHTWGC LFSTFTST

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KRT10-AS1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 3
Mean surface accessibility (rSASA): 0.57

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KRT10-AS1 as an antibody target. Whether an autoantibody or antibody against KRT10-AS1 could matter depends on whether native KRT10-AS1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KRT10-AS1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KRT10-AS1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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