Seroatlas · Human Serome Atlas

KREMEN2

Kremen protein 2

Also known as: KREM2_HUMAN, KRM2, MGC10791

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8NCW0
Gene
KREMEN2
Ensembl
ENSG00000131650
Chromosome
16
Canonical length
462 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Secretome location
Intracellular and membrane

OverviewNCBI Gene

This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor. A similar protein in mouse functions interacts with with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein forms a ternary membrane complex with DKK1 and the WNT receptor lipoprotein receptor-related protein 6 (LRP6), and induces rapid endocytosis and removal of LRP6 from the plasma membrane. It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

Canonical amino-acid sequenceUniProt

462 residues, UniProt reviewed canonical sequence.

>Q8NCW0|KREMEN2
     1  MGTQALQGFL FLLFLPLLQP RGASAGSLHS PGLSECFQVN GADYRGHQNR TGPRGAGRPC
    61  LFWDQTQQHS YSSASDPHGR WGLGAHNFCR NPDGDVQPWC YVAETEEGIY WRYCDIPSCH
   121  MPGYLGCFVD SGAPPALSGP SGTSTKLTVQ VCLRFCRMKG YQLAGVEAGY ACFCGSESDL
   181  ARGRLAPATD CDQICFGHPG QLCGGDGRLG VYEVSVGSCQ GNWTAPQGVI YSPDFPDEYG
   241  PDRNCSWALG PPGAALELTF RLFELADPRD RLELRDAASG SLLRAFDGAR PPPSGPLRLG
   301  TAALLLTFRS DARGHAQGFA LTYRGLQDAA EDPEAPEGSA QTPAAPLDGA NVSCSPRPGA
   361  PPAAIGARVF STVTAVSVLL LLLLGLLRPL RRRSCLLAPG KGPPALGASR GPRRSWAVWY
   421  QQPRGVALPC SPGDPQAEGS AAGYRPLSAS SQSSLRSLIS AL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KREMEN2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
7.5 nTPM

Expression across tissuesHPA

Tissue

  • skin: 7.5 nTPM
  • retina: 3.8 nTPM
  • thymus: 2 nTPM
  • esophagus: 1.9 nTPM
  • cerebral cortex: 1.8 nTPM
  • testis: 1.7 nTPM

Single-cell type

  • tuft cells: 46 nCPM
  • rod photoreceptor cells: 33 nCPM
  • early primary spermatocytes: 30 nCPM
  • goblet cells: 19 nCPM
  • medullary thymic epithelial cells: 17 nCPM
  • epididymal basal cells: 15 nCPM

Immune cell

  • naive B-cell: 1.3 nTPM
  • memory B-cell: 1.2 nTPM
  • non-classical monocyte: 0.4 nTPM
  • myeloid DC: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM

Brain region

  • cerebral cortex: 9.1 nTPM
  • hippocampal formation: 8 nTPM
  • amygdala: 7.7 nTPM
  • white matter: 6.6 nTPM
  • basal ganglia: 5.3 nTPM
  • medulla oblongata: 4.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.92
gnomAD pLI
0
gnomAD missense Z
1.51
DepMap mean gene effect
-0.14
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KREMEN2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KREMEN2 as an antibody target. Whether an autoantibody or antibody against KREMEN2 could matter depends on whether native KREMEN2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KREMEN2 is annotated at the cell surface, where native KREMEN2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label KREMEN2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KREMEN2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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