Seroatlas · Human Serome Atlas

KREMEN1

Kremen protein 1

Also known as: KREM1_HUMAN, KREMEN, KRM1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96MU8
Gene
KREMEN1
Ensembl
ENSG00000183762
Chromosome
22
Canonical length
473 aa
Protein class
Disease related genes, Human disease related genes, Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein is a component of a membrane complex that modulates canonical WNT signaling through lipoprotein receptor-related protein 6 (LRP6). It contains extracellular kringle, WSC, and CUB domains. Mutations in this gene result in ectodermal dysplasia. This protein has also been found to be a functional receptor for Coxsackievirus A10 and may be an alternative entry receptor for SARS-CoV-2. [provided by RefSeq, Nov 2021]

Canonical amino-acid sequenceUniProt

473 residues, UniProt reviewed canonical sequence.

>Q96MU8|KREMEN1
     1  MAPPAARLAL LSAAALTLAA RPAPSPGLGP ECFTANGADY RGTQNWTALQ GGKPCLFWNE
    61  TFQHPYNTLK YPNGEGGLGE HNYCRNPDGD VSPWCYVAEH EDGVYWKYCE IPACQMPGNL
   121  GCYKDHGNPP PLTGTSKTSN KLTIQTCISF CRSQRFKFAG MESGYACFCG NNPDYWKYGE
   181  AASTECNSVC FGDHTQPCGG DGRIILFDTL VGACGGNYSA MSSVVYSPDF PDTYATGRVC
   241  YWTIRVPGAS HIHFSFPLFD IRDSADMVEL LDGYTHRVLA RFHGRSRPPL SFNVSLDFVI
   301  LYFFSDRINQ AQGFAVLYQA VKEELPQERP AVNQTVAEVI TEQANLSVSA ARSSKVLYVI
   361  TTSPSHPPQT VPGSNSWAPP MGAGSHRVEG WTVYGLATLL ILTVTAIVAK ILLHVTFKSH
   421  RVPASGDLRD CHQPGTSGEI WSIFYKPSTS ISIFKKKLKG QSQQDDRNPL VSD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KREMEN1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.42
Highest tissue expression
45 nTPM

Expression across tissuesHPA

Tissue

  • parathyroid gland: 45 nTPM
  • tongue: 40 nTPM
  • esophagus: 35 nTPM
  • skin: 34 nTPM
  • skeletal muscle: 27 nTPM
  • salivary gland: 27 nTPM

Single-cell type

  • neutrophils: 501 nCPM
  • myosatellite cells: 226 nCPM
  • esophageal apical cells: 207 nCPM
  • bergmann glia: 152 nCPM
  • pituitary stem cells: 146 nCPM
  • erythrocyte progenitors: 125 nCPM

Immune cell

  • neutrophil: 4.5 nTPM
  • basophil: 1.3 nTPM
  • plasmacytoid DC: 0.6 nTPM
  • NK-cell: 0.3 nTPM
  • classical monocyte: 0.2 nTPM
  • intermediate monocyte: 0.2 nTPM

Brain region

  • basal ganglia: 46 nTPM
  • thalamus: 26 nTPM
  • hippocampal formation: 26 nTPM
  • cerebral cortex: 21 nTPM
  • amygdala: 21 nTPM
  • midbrain: 20 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about KREMEN1.

Disease | AllUniProt

Conditions KREMEN1 is implicated in, by any mechanism.

  • Ectodermal dysplasia 13, hair/tooth type (ECTD13) MIM:617392

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 142 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.64
gnomAD pLI
0.01
gnomAD missense Z
0.78
DepMap mean gene effect
0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KREMEN1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KREMEN1 as an antibody target. Whether an autoantibody or antibody against KREMEN1 could matter depends on whether native KREMEN1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KREMEN1 is annotated at the cell surface, where native KREMEN1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label KREMEN1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KREMEN1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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