Seroatlas · Human Serome Atlas

KRBA1

Protein KRBA1

Also known as: KIAA1862, KRBA1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A5PL33
Gene: KRBA1
Ensembl: ENSG00000133619
Chromosome: 7
Canonical length: 1030 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to be involved in regulation of DNA-templated transcription. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1030 residues, UniProt reviewed canonical sequence.

>A5PL33|KRBA1
     1  MRENYETLVS VGTAELLPLS AFLSPSEPGR AVGGGSHADE GQEPAGCGDP QGGQPRHSLH
    61  LTALVQLVKE IPEFLFGEVK GAMDSPESES RGASLDGERA SPEAAAAREP CPLRGLLSCL
   121  PDGPTSQPHL ATTPTDSSCS SGPTGDGVQG SPLPIKTADK PWPTRKEGPG ALGGEPSPPT
   181  HSPSRRKSHR GQERGTSEAG ISPGNSPLQG LINCLKEILV PGPRHPETSP SFLPPLPSLG
   241  TSRLTRADLG PGSPPWAVKT EAVSGDCPLQ GLLHCLKELP EAQDRHPSPS GVGNRRLQEN
   301  PGAWKRGSGG PGYLLTPPPH PDLGAGGLLS VKMENSWVQS PPGPASCQPG RQPLSPSATG
   361  DTRGVPQPSW GPEAQAASAS SSPLEALEAC LKGIPPNGSS PSQLPPTSCS QNPQPGDSRS
   421  QKPELQPHRS HSEEATREPV LPLGLQSCVR DGPSRPLAPR GTPTSFSSSS STDWDLDFGS
   481  PVGNQGQHPG KGSPPGSSPL QGLENCLKEI PVPVLRPAWP CSSAADRGPR RAEPRNWTAD
   541  KEGLRAEACE SARLGQGRGE APTRSLHLVS PQVFTSSCVP ACHQRGFKDP GATRPGVWRW
   601  LPEGSAPKPS PLHCLESALR GILPVRPLRF ACVGGPSPSP SPGSSSSFSG SEGEDPRPEP
   661  DLWKPLPQER DRLPSCKPPV PLSPCPGGTP AGSSGGSPGE DPRRTEPRYC SGLGAGTAQD
   721  PCPVSQLEKR PRVSEASRGL ELGHGRPRVA AKTHERLLPQ GPPELPSESP PPELPPPEAA
   781  PPVLPASSLQ PPCHCGKPLQ QELHSLGAAL AEKLDRLATA LAGLAQEVAT MRTQVNRLGR
   841  RPQGPGPMGQ ASWMWTLPRG PRWAHGPGHR HLPYWRQKGP TRPKPKILRG QGESCRAGDL
   901  QGLSRGTARR ARPLPPDAPP AEPPGLHCSS SQQLLSSTPS CHAAPPAHPL LAHTGGHQSP
   961  LPPLVPAALP LQGASPPAAS ADADVPTSGV APDGIPERPK EPSSLLGGVQ RALQEELWGG
  1021  EHRDPRWGAH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KRBA1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.7
Highest tissue expression: 38 nTPM

Expression across tissuesHPA

Tissue

heart muscle: 38 nTPM
pituitary gland: 24 nTPM
cerebellum: 12 nTPM
salivary gland: 12 nTPM
cerebral cortex: 12 nTPM
endometrium: 9.3 nTPM

Single-cell type

cardiomyocytes: 48 nCPM
corticotrophs: 20 nCPM
epicardial cells: 18 nCPM
müller glia: 17 nCPM
epididymal clear cells: 14 nCPM
somatotrophs: 13 nCPM

Immune cell

non-classical monocyte: 1.6 nTPM
T-reg: 1.6 nTPM
plasmacytoid DC: 1.4 nTPM
gdT-cell: 1.3 nTPM
naive B-cell: 1.3 nTPM
naive CD4 T-cell: 1.2 nTPM

Brain region

cerebral cortex: 33 nTPM
medulla oblongata: 28 nTPM
white matter: 27 nTPM
amygdala: 24 nTPM
thalamus: 24 nTPM
basal ganglia: 23 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.11
gnomAD pLI: 0
gnomAD missense Z: 0.56

Protein domainsUniProt · Pfam · InterPro

KRBA1 family repeat
KRBA1
KRBA1 family repeat

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KRBA1 as an antibody target. Whether an autoantibody or antibody against KRBA1 could matter depends on whether native KRBA1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KRBA1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KRBA1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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