Seroatlas · Human Serome Atlas

KPRP

Keratinocyte proline-rich protein

Also known as: C1orf45, KPRP_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5T749
Gene: KPRP
Ensembl: ENSG00000203786
Chromosome: 1
Canonical length: 579 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a proline-rich skin protein possibly involved in keratinocyte differentiation. [provided by RefSeq, Jul 2016]

Canonical amino-acid sequenceUniProt

579 residues, UniProt reviewed canonical sequence.

>Q5T749|KPRP
     1  MCDQQQIQCR LPLQQCCVKG PSFCSSQSPF AQSQVVVQAP CEMQIVDCPA SCPVQVCQVS
    61  DQAPCQSQTT QVKCQSKTKQ VKGQAQCQSK TTQVKGQAAS QSQTSSVQSQ APCQSEVSYV
   121  QCEASQPVQT CFVECAPVCY TETCYVECPV QNYVPCPAPQ PVQMYRGRPA VCQPQGRFST
   181  QCQYQGSYSS CGPQFQSRAT CNNYTPQFQL RPSYSSCFPQ YRSRTSFSPC VPQCQTQGSY
   241  GSFTEQHRSR STSRCLPPPR RLQLFPRSCS PPRRFEPCSS SYLPLRPSEG FPNYCTPPRR
   301  SEPIYNSRCP RRPISSCSQR RGPKCRIEIS SPCCPRQVPP QRCPVEIPPI RRRSQSCGPQ
   361  PSWGASCPEL RPHVEPRPLP SFCPPRRLDQ CPESPLQRCP PPAPRPRLRP EPCISLEPRP
   421  RPLPRQLSEP CLYPEPLPAL RPTPRPVPLP RPGQCEIPEP RPCLQPCEHP EPCPRPEPIP
   481  LPAPCPSPEP CRETWRSPSP CWGPNPVPYP GDLGCHESSP HRLDTEAPYC GPSSYNQGQE
   541  SGAGCGPGDV FPERRGQDGH GDQGNAFAGV KGEAKSAYF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KPRP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.75
Highest tissue expression: 318 nTPM

Expression across tissuesHPA

Tissue

skin: 318 nTPM
esophagus: 20 nTPM
breast: 9.5 nTPM
cervix: 7.1 nTPM
vagina: 6.9 nTPM
salivary gland: 4.7 nTPM

Single-cell type

esophageal apical cells: 75 nCPM
suprabasal keratinocytes: 2.6 nCPM
ocular epithelial cells: 1.2 nCPM
esophageal suprabasal cells: 0.6 nCPM
basal keratinocytes: 0.3 nCPM
esophageal basal cells: 0.2 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

basal ganglia: 1.9 nTPM
pons: 0.3 nTPM
cerebral cortex: 0.2 nTPM
medulla oblongata: 0.2 nTPM
thalamus: 0.1 nTPM
amygdala: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.78
gnomAD pLI: 0
gnomAD missense Z: -0.5
DepMap mean gene effect: 0.18
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Keratinocyte Proline-Rich

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KPRP as an antibody target. Whether an autoantibody or antibody against KPRP could matter depends on whether native KPRP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KPRP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KPRP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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