Seroatlas · Human Serome Atlas

KPLCE

Protein KPLCE

Also known as: C1orf68, KPLCE_HUMAN, LEP7, XP32

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5T750
Gene: KPLCE
Ensembl: ENSG00000198854
Chromosome: 1
Canonical length: 250 aa
Protein class: Predicted intracellular proteins
Subcellular location: Plasma membrane,Cytosol

OverviewNCBI Gene

Predicted to be involved in epidermis development. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

250 residues, UniProt reviewed canonical sequence.

>Q5T750|KPLCE
     1  MCDQQKQPQF PPSCVKGSGL GAGQGSNGAS VKCPVPCQTQ TVCVTGPAPC PTQTYVKYQV
    61  PCQTQTYVKC PAPCQRTYVK YPTPCQTYVK CPAPCQTTYV KCPTPCQTYV KCPAPCQMTY
   121  IKSPAPCQTQ TCYVQGASPC QSYYVQAPAS GSTSQYCVTD PCSAPCSTSY CCLAPRTFGV
   181  SPLRRWIQRP QNCNTGSSGC CENSGSSGCC GSGGCGCSCG CGSSGCCCLG IIPMRSRGPA
   241  CCDHEDDCCC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KPLCE can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 640 nTPM

Expression across tissuesHPA

Tissue

skin: 640 nTPM
breast: 40 nTPM
skeletal muscle: 3.5 nTPM
salivary gland: 0.3 nTPM
adipose tissue: 0.2 nTPM
bone marrow: 0.2 nTPM

Single-cell type

suprabasal keratinocytes: 28 nCPM
late spermatids: 1.1 nCPM
epididymal basal cells: 0.8 nCPM
early spermatids: 0.4 nCPM
basal keratinocytes: 0.2 nCPM
esophageal basal cells: 0.2 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.77
gnomAD pLI: 0
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

epidermis development

Protein domainsUniProt · Pfam · InterPro

Protein KPLCE

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KPLCE as an antibody target. Whether an autoantibody or antibody against KPLCE could matter depends on whether native KPLCE is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KPLCE is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KPLCE as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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