Seroatlas · Human Serome Atlas

KNCN

Kinocilin

Also known as: FLJ32011, KINO, KNCN_HUMAN, L5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A6PVL3
Gene
KNCN
Ensembl
ENSG00000162456
Chromosome
1
Canonical length
124 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

Predicted to be located in several cellular components, including apical part of cell; cytoplasm; and microtubule cytoskeleton. Predicted to be active in several cellular components, including apical plasma membrane; cytoskeleton; and kinocilium. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

124 residues, UniProt reviewed canonical sequence.

>A6PVL3|KNCN
     1  MDIPISSRDF RGLQLACVAL GLVAGSIIIG ISVSKAAAAM GGVFIGAAVL GLLILAYPFL
    61  KARFNLDHIL PTIGSLRIHP HPGADHGEGR SSTNGNKEGA RSSLSTVSRT LEKLKPGTRG
   121  AEEC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KNCN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
2
Mean surface accessibility (rSASA)
0.57
Highest tissue expression
1 nTPM

Expression across tissuesHPA

Tissue

  • hypothalamus: 1 nTPM
  • midbrain: 0.4 nTPM
  • pituitary gland: 0.3 nTPM
  • cerebral cortex: 0.2 nTPM
  • testis: 0.2 nTPM
  • amygdala: 0.1 nTPM

Single-cell type

  • late spermatids: 54 nCPM
  • early spermatids: 15 nCPM
  • late primary spermatocytes: 7.5 nCPM
  • epididymal efferent duct ciliated cells: 4.6 nCPM
  • ependymal cells: 4.4 nCPM
  • fallopian tube ciliated cells: 3.6 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • hypothalamus: 7.3 nTPM
  • midbrain: 5.4 nTPM
  • pons: 4.7 nTPM
  • medulla oblongata: 4 nTPM
  • thalamus: 1.6 nTPM
  • cerebral cortex: 1.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.96
gnomAD pLI
0
gnomAD missense Z
-0.37
DepMap mean gene effect
-0.09
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Kinocilin protein
  • Kinocilin protein

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KNCN as an antibody target. Whether an autoantibody or antibody against KNCN could matter depends on whether native KNCN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KNCN is annotated at the cell surface, where native KNCN is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label KNCN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KNCN. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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