Seroatlas · Human Serome Atlas

KMO

Kynurenine 3-monooxygenase

Also known as: KMO_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O15229
Gene: KMO
Ensembl: ENSG00000117009
Chromosome: 1
Canonical length: 486 aa
Protein class: Enzymes, Metabolic proteins, Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a mitochondrion outer membrane protein that catalyzes the hydroxylation of L-tryptophan metabolite, L-kynurenine, to form L-3-hydroxykynurenine. Studies in yeast identified this gene as a therapeutic target for Huntington disease. [provided by RefSeq, Oct 2011]

Canonical amino-acid sequenceUniProt

486 residues, UniProt reviewed canonical sequence.

>O15229|KMO
     1  MDSSVIQRKK VAVIGGGLVG SLQACFLAKR NFQIDVYEAR EDTRVATFTR GRSINLALSH
    61  RGRQALKAVG LEDQIVSQGI PMRARMIHSL SGKKSAIPYG TKSQYILSVS RENLNKDLLT
   121  AAEKYPNVKM HFNHRLLKCN PEEGMITVLG SDKVPKDVTC DLIVGCDGAY STVRSHLMKK
   181  PRFDYSQQYI PHGYMELTIP PKNGDYAMEP NYLHIWPRNT FMMIALPNMN KSFTCTLFMP
   241  FEEFEKLLTS NDVVDFFQKY FPDAIPLIGE KLLVQDFFLL PAQPMISVKC SSFHFKSHCV
   301  LLGDAAHAIV PFFGQGMNAG FEDCLVFDEL MDKFSNDLSL CLPVFSRLRI PDDHAISDLS
   361  MYNYIEMRAH VNSSWFIFQK NMERFLHAIM PSTFIPLYTM VTFSRIRYHE AVQRWHWQKK
   421  VINKGLFFLG SLIAISSTYL LIHYMSPRSF LRLRRPWNWI AHFRNTTCFP AKAVDSLEQI
   481  SNLISR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KMO can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 86 nTPM

Expression across tissuesHPA

Tissue

liver: 86 nTPM
kidney: 29 nTPM
tonsil: 11 nTPM
lymph node: 8.3 nTPM
spleen: 7.9 nTPM
placenta: 6.4 nTPM

Single-cell type

syncytiotrophoblasts: 453 nCPM
monocytes: 289 nCPM
macrophages: 203 nCPM
kupffer cells: 192 nCPM
endometrial glandular cells: 145 nCPM
cdc: 127 nCPM

Immune cell

naive B-cell: 42 nTPM
memory B-cell: 36 nTPM
non-classical monocyte: 34 nTPM
intermediate monocyte: 32 nTPM
plasmacytoid DC: 24 nTPM
myeloid DC: 11 nTPM

Brain region

thalamus: 4.4 nTPM
cerebral cortex: 3.9 nTPM
choroid plexus: 3.6 nTPM
white matter: 2.9 nTPM
basal ganglia: 2.6 nTPM
amygdala: 2.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.7
gnomAD pLI: 0
gnomAD missense Z: 1.83
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KMO as an antibody target. Whether an autoantibody or antibody against KMO could matter depends on whether native KMO is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KMO is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KMO as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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