KLLN
Killin
Also known as: KILIN_HUMAN, killin
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- B2CW77
- Gene
- KLLN
- Ensembl
- ENSG00000227268
- Chromosome
- 10
- Canonical length
- 178 aa
- Protein class
- Disease related genes, Human disease related genes, Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Nucleoli
OverviewNCBI Gene
The protein encoded by this intronless gene is found in the nucleus, where it can inhibit DNA synthesis and promote S phase arrest coupled to apoptosis. The expression of this DNA binding protein is upregulated by transcription factor p53. [provided by RefSeq, Dec 2012]
Canonical amino-acid sequenceUniProt
178 residues, UniProt reviewed canonical sequence.
>B2CW77|KLLN
1 MDRPGPGSAR PGRTVHVWGY RVEWKVRNGR KLQPSEWAGR GDLGGFKRRW KDTRATVGTT
61 FRRRSRVSLV GELSKFPLPS DSSGGKSSSS FARGALAWCR QRNPNPSCAA AETGARTSLP
121 KERCRGWRLG NWLHKHPHPN TCPRLPACWL PPILTERGER VPKLVPLLAC YPKSKPKDLocalizationUniProt · AlphaFold · HPA
Whether an antibody against KLLN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.72
- Highest tissue expression
- 4.1 nTPM
Expression across tissuesHPA
Tissue
- skeletal muscle: 4.1 nTPM
- fallopian tube: 1.3 nTPM
- thymus: 1 nTPM
- adipose tissue: 0.9 nTPM
- epididymis: 0.9 nTPM
- testis: 0.9 nTPM
Single-cell type
- papillary tip epithelial cells: 1.1 nCPM
- other brain neurons: 1 nCPM
- brain excitatory neurons: 0.8 nCPM
- brain inhibitory neurons: 0.7 nCPM
- ependymal cells: 0.7 nCPM
- renal collecting duct principal cells: 0.6 nCPM
Immune cell
- neutrophil: 2.5 nTPM
- basophil: 1.5 nTPM
- non-classical monocyte: 0.8 nTPM
- NK-cell: 0.6 nTPM
- eosinophil: 0.5 nTPM
- intermediate monocyte: 0.5 nTPM
Brain region
- cerebral cortex: 4.8 nTPM
- cerebellum: 4.6 nTPM
- white matter: 4.6 nTPM
- amygdala: 3.8 nTPM
- hypothalamus: 3.4 nTPM
- hippocampal formation: 3.2 nTPM
DiseaseUniProt · ClinVar · IEDB · PubMed
Four sources answering four different questions about KLLN.
Disease | AllUniProt
Conditions KLLN is implicated in, by any mechanism.
- Cowden syndrome 4 (CWS4) MIM:615107
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.89
- gnomAD pLI
- 0.01
- gnomAD missense Z
- -0.97
- DepMap mean gene effect
- -0.04
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads KLLN as an antibody target. Whether an autoantibody or antibody against KLLN could matter depends on whether native KLLN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
KLLN is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label KLLN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
Loading the interactive Seroatlas protein explorer...