Seroatlas · Human Serome Atlas

KLKP1

Putative protein KRIP1

Also known as: KRIP1_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q107X0
Gene: KLKP1
Canonical length: 134 aa

OverviewNCBI Gene

No narrative summary is available for KLKP1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

134 residues, UniProt reviewed canonical sequence.

>Q107X0|KLKP1
     1  MSPVHRSRTS QTQEAHKPTS TLSFISPPQP PRQDPKSPHI LCSQPNACSR QSHVSYPNPW
    61  GLPCSQSKVS PPGTATNPNP KEWSRISGPP VSLDPQPWSS APFKPTAQLP LLAQSLGPPA
   121  KPALPDPALP LQML

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KLKP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.7

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KLKP1 as an antibody target. Whether an autoantibody or antibody against KLKP1 could matter depends on whether native KLKP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KLKP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KLKP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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