KLK9
Kallikrein-9
Also known as: KLK-L3, KLK9_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9UKQ9
- Gene
- KLK9
- Ensembl
- ENSG00000213022
- Chromosome
- 19
- Canonical length
- 250 aa
- Protein class
- Cancer-related genes, Enzymes, Predicted secreted proteins
- Secretome location
- Secreted in other tissues
OverviewNCBI Gene
The protein encoded by this gene is a kallikrein-related serine protease. This gene is activated by steroid hormones in a human breast cancer cell line, making it a good marker for cancer detection. The encoded protein is found primarily in the cytoplasm.[provided by RefSeq, Oct 2010]
Canonical amino-acid sequenceUniProt
250 residues, UniProt reviewed canonical sequence.
>Q9UKQ9|KLK9
1 MKLGLLCALL SLLAGHGWAD TRAIGAEECR PNSQPWQAGL FHLTRLFCGA TLISDRWLLT
61 AAHCRKPYLW VRLGEHHLWK WEGPEQLFRV TDFFPHPGFN KDLSANDHND DIMLIRLPRQ
121 ARLSPAVQPL NLSQTCVSPG MQCLISGWGA VSSPKALFPV TLQCANISIL ENKLCHWAYP
181 GHISDSMLCA GLWEGGRGSC QGDSGGPLVC NGTLAGVVSG GAEPCSRPRR PAVYTSVCHY
241 LDWIQEIMENLocalizationUniProt · AlphaFold · HPA
Whether an antibody against KLK9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.28
- Highest tissue expression
- 11 nTPM
Expression across tissuesHPA
Tissue
- skin: 11 nTPM
- cervix: 6.4 nTPM
- esophagus: 5 nTPM
- vagina: 2.3 nTPM
- tonsil: 1.6 nTPM
- salivary gland: 0.7 nTPM
Single-cell type
- adipocytes: 0 nCPM
- adrenal cortex cells: 0 nCPM
- adrenal medulla cells: 0 nCPM
- alveolar cells type 1: 0 nCPM
- alveolar cells type 2: 0 nCPM
- astrocytes: 0 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- amygdala: 0 nTPM
- basal ganglia: 0 nTPM
- cerebellum: 0 nTPM
- cerebral cortex: 0 nTPM
- choroid plexus: 0 nTPM
- hippocampal formation: 0 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.53
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.11
- DepMap mean gene effect
- 0.11
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads KLK9 as an antibody target. Whether an autoantibody or antibody against KLK9 could matter depends on whether native KLK9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
KLK9 is annotated as secreted, so native KLK9 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label KLK9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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