Seroatlas · Human Serome Atlas

KLK7

Kallikrein-7

Also known as: KLK7_HUMAN, PRSS6, SCCE

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P49862
Gene
KLK7
Ensembl
ENSG00000169035
Chromosome
19
Canonical length
253 aa
Protein class
Cancer-related genes, Enzymes, Predicted intracellular proteins, Predicted secreted proteins
Subcellular location
Nuclear membrane,Plasma membrane
Secretome location
Secreted in other tissues

OverviewNCBI Gene

This gene encodes a member of the kallikrein subfamily of serine proteases. These enzymes have diverse physiological functions and many kallikrein genes are biomarkers for cancer. The encoded protein has chymotrypsin-like activity and plays a role in the proteolysis of intercellular cohesive structures that precedes desquamation, the shedding of the outermost layer of the epidermis. The encoded protein may play a role in cancer invasion and metastasis, and increased expression of this gene is associated with unfavorable prognosis and progression of several types of cancer. Polymorphisms in this gene may play a role in the development of atopic dermatitis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, which is one of fifteen kallikrein subfamily members located in a gene cluster on chromosome 19. [provided by RefSeq, May 2011]

Canonical amino-acid sequenceUniProt

253 residues, UniProt reviewed canonical sequence.

>P49862|KLK7
     1  MARSLLLPLQ ILLLSLALET AGEEAQGDKI IDGAPCARGS HPWQVALLSG NQLHCGGVLV
    61  NERWVLTAAH CKMNEYTVHL GSDTLGDRRA QRIKASKSFR HPGYSTQTHV NDLMLVKLNS
   121  QARLSSMVKK VRLPSRCEPP GTTCTVSGWG TTTSPDVTFP SDLMCVDVKL ISPQDCTKVY
   181  KDLLENSMLC AGIPDSKKNA CNGDSGGPLV CRGTLQGLVS WGTFPCGQPN DPGVYTQVCK
   241  FTKWINDTMK KHR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KLK7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
189 nTPM

Expression across tissuesHPA

Tissue

  • skin: 189 nTPM
  • esophagus: 91 nTPM
  • cervix: 41 nTPM
  • vagina: 30 nTPM
  • salivary gland: 21 nTPM
  • amygdala: 16 nTPM

Single-cell type

  • esophageal apical cells: 1,071 nCPM
  • salivary duct cells: 307 nCPM
  • esophageal suprabasal cells: 151 nCPM
  • salivary acinar cells: 71 nCPM
  • salivary basal cells: 55 nCPM
  • breast secretory cells: 45 nCPM

Immune cell

  • basophil: 0.2 nTPM
  • NK-cell: 0.1 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • cerebral cortex: 19 nTPM
  • amygdala: 18 nTPM
  • hypothalamus: 14 nTPM
  • hippocampal formation: 12 nTPM
  • pons: 10 nTPM
  • basal ganglia: 8.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.29
gnomAD pLI
0
gnomAD missense Z
-0.03
DepMap mean gene effect
0.1
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KLK7 as an antibody target. Whether an autoantibody or antibody against KLK7 could matter depends on whether native KLK7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KLK7 is annotated at the cell surface, where native KLK7 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label KLK7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KLK7. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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