KLK5

Protein identityUniProt · HPA

UniProt accession

Q9Y337

Gene

KLK5

Ensembl

ENSG00000167754

Chromosome

19

Canonical length

293 aa

Protein class

Cancer-related genes, Enzymes, Predicted secreted proteins

Secretome location

Secreted in other tissues

OverviewNCBI Gene

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its expression is up-regulated by estrogens and progestins. The encoded protein is secreted and may be involved in desquamation in the epidermis. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

293 residues, UniProt reviewed canonical sequence.

>Q9Y337|KLK5
     1  MATARPPWMW VLCALITALL LGVTEHVLAN NDVSCDHPSN TVPSGSNQDL GAGAGEDARS
    61  DDSSSRIING SDCDMHTQPW QAALLLRPNQ LYCGAVLVHP QWLLTAAHCR KKVFRVRLGH
   121  YSLSPVYESG QQMFQGVKSI PHPGYSHPGH SNDLMLIKLN RRIRPTKDVR PINVSSHCPS
   181  AGTKCLVSGW GTTKSPQVHF PKVLQCLNIS VLSQKRCEDA YPRQIDDTMF CAGDKAGRDS
   241  CQGDSGGPVV CNGSLQGLVS WGDYPCARPN RPGVYTNLCK FTKWIQETIQ ANS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KLK5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.35

Highest tissue expression

196 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1

gnomAD pLI

0.01

gnomAD missense Z

0.29

DepMap mean gene effect

-0.03

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• amelogenesis
• antibacterial peptide biosynthetic process
• cornification
• epidermis development
• extracellular matrix disassembly
• positive regulation of G protein-coupled receptor signaling pathway
• protein maturation
• proteolysis

Molecular functions

• peptidase activity
• serine-type endopeptidase activity
• serine-type peptidase activity

Cellular components

• cytosol
• epidermal lamellar body
• extracellular region
• extracellular space
• secretory granule

Protein domainsUniProt · Pfam · InterPro

• Serine proteases, trypsin domain
• Peptidase S1A, chymotrypsin family
• Peptidase S1, PA clan
• Serine proteases, trypsin family, histidine active site
• Serine proteases, trypsin family, serine active site
• Trypsin

KeywordsUniProt

• Disulfide bond
• Glycoprotein
• Hydrolase
• Protease
• Secreted
• Serine protease
• Signal

InteractionsUniProt · HPA

Protein binding partners of KLK5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• SPINK9