Seroatlas · Human Serome Atlas

KLK14

Kallikrein-14

Also known as: KLK-L6, KLK14_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9P0G3
Gene: KLK14
Ensembl: ENSG00000129437
Chromosome: 19
Canonical length: 267 aa
Protein class: Cancer-related genes, Enzymes, Plasma proteins, Predicted secreted proteins
Secretome location: Secreted in other tissues

OverviewNCBI Gene

This gene encodes a member of the kallikrein subfamily of serine proteases that have diverse physiological functions such as regulation of blood pressure and desquamation. The altered expression of this gene is implicated in the progression of different cancers including breast and prostate tumors. The encoded protein is a precursor that is proteolytically processed to generate the functional enzyme. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]

Canonical amino-acid sequenceUniProt

267 residues, UniProt reviewed canonical sequence.

>Q9P0G3|KLK14
     1  MSLRVLGSGT WPSAPKMFLL LTALQVLAIA MTQSQEDENK IIGGHTCTRS SQPWQAALLA
    61  GPRRRFLCGG ALLSGQWVIT AAHCGRPILQ VALGKHNLRR WEATQQVLRV VRQVTHPNYN
   121  SRTHDNDLML LQLQQPARIG RAVRPIEVTQ ACASPGTSCR VSGWGTISSP IARYPASLQC
   181  VNINISPDEV CQKAYPRTIT PGMVCAGVPQ GGKDSCQGDS GGPLVCRGQL QGLVSWGMER
   241  CALPGYPGVY TNLCKYRSWI EETMRDK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KLK14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 9.9 nTPM

Expression across tissuesHPA

Tissue

skin: 9.9 nTPM
vagina: 4 nTPM
cervix: 2.3 nTPM
cerebellum: 2.1 nTPM
breast: 1.5 nTPM
basal ganglia: 1.3 nTPM

Single-cell type

tuft cells: 12 nCPM
breast hormone-responsive cells: 5.5 nCPM
respiratory secretory cells: 3.7 nCPM
suprabasal keratinocytes: 3.5 nCPM
transitional alveolar cells: 2.3 nCPM
retinal horizontal cells: 2 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 3.3 nTPM
cerebellum: 2.6 nTPM
white matter: 2.4 nTPM
basal ganglia: 2.3 nTPM
hippocampal formation: 2.3 nTPM
pons: 2.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.57
gnomAD pLI: 0
gnomAD missense Z: 0.39
DepMap mean gene effect: 0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

serine-type endopeptidase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KLK14 as an antibody target. Whether an autoantibody or antibody against KLK14 could matter depends on whether native KLK14 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KLK14 is annotated as secreted, so native KLK14 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label KLK14 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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