Seroatlas · Human Serome Atlas

KLK11

Kallikrein-11

Also known as: KLK11_HUMAN, PRSS20, TLSP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UBX7
Gene
KLK11
Ensembl
ENSG00000167757
Chromosome
19
Canonical length
282 aa
Protein class
Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins
Secretome location
Secreted in other tissues

OverviewNCBI Gene

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing and the use of alternate promoters results in multiple transcript variants encoding distinct isoforms which are differentially expressed. [provided by RefSeq, Dec 2016]

Canonical amino-acid sequenceUniProt

282 residues, UniProt reviewed canonical sequence.

>Q9UBX7|KLK11
     1  MQRLRWLRDW KSSGRGLTAA KEPGARSSPL QAMRILQLIL LALATGLVGG ETRIIKGFEC
    61  KPHSQPWQAA LFEKTRLLCG ATLIAPRWLL TAAHCLKPRY IVHLGQHNLQ KEEGCEQTRT
   121  ATESFPHPGF NNSLPNKDHR NDIMLVKMAS PVSITWAVRP LTLSSRCVTA GTSCLISGWG
   181  STSSPQLRLP HTLRCANITI IEHQKCENAY PGNITDTMVC ASVQEGGKDS CQGDSGGPLV
   241  CNQSLQGIIS WGQDPCAITR KPGVYTKVCK YVDWIQETMK NN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KLK11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
311 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 311 nTPM
  • skin: 230 nTPM
  • vagina: 179 nTPM
  • salivary gland: 161 nTPM
  • choroid plexus: 129 nTPM
  • cervix: 126 nTPM

Single-cell type

  • esophageal apical cells: 2,907 nCPM
  • esophageal suprabasal cells: 1,082 nCPM
  • late spermatids: 531 nCPM
  • suprabasal keratinocytes: 484 nCPM
  • respiratory secretory cells: 392 nCPM
  • parietal cells: 237 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • choroid plexus: 96 nTPM
  • hippocampal formation: 3.7 nTPM
  • cerebellum: 2 nTPM
  • thalamus: 1.5 nTPM
  • pons: 0.7 nTPM
  • medulla oblongata: 0.4 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about KLK11.

Disease | AllUniProt

Conditions KLK11 is implicated in, by any mechanism.

  • Ichthyosis with erythrokeratoderma (IEKD) MIM:620507

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 60 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Ichthyosis with erythrokeratoderma

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.98
gnomAD pLI
0
gnomAD missense Z
0.68
DepMap mean gene effect
0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KLK11 as an antibody target. Whether an autoantibody or antibody against KLK11 could matter depends on whether native KLK11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KLK11 is annotated as secreted, so native KLK11 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label KLK11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KLK11. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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