KLK10
Kallikrein-10
Also known as: KLK10_HUMAN, NES1, PRSSL1
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- O43240
- Gene
- KLK10
- Ensembl
- ENSG00000129451
- Chromosome
- 19
- Canonical length
- 276 aa
- Protein class
- Cancer-related genes, Enzymes, Predicted secreted proteins
- Secretome location
- Secreted in other tissues
OverviewNCBI Gene
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its encoded protein is secreted and may play a role in suppression of tumorigenesis in breast and prostate cancers. Alternate splicing of this gene results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
276 residues, UniProt reviewed canonical sequence.
>O43240|KLK10
1 MRAPHLHLSA ASGARALAKL LPLLMAQLWA AEAALLPQND TRLDPEAYGS PCARGSQPWQ
61 VSLFNGLSFH CAGVLVDQSW VLTAAHCGNK PLWARVGDDH LLLLQGEQLR RTTRSVVHPK
121 YHQGSGPILP RRTDEHDLML LKLARPVVLG PRVRALQLPY RCAQPGDQCQ VAGWGTTAAR
181 RVKYNKGLTC SSITILSPKE CEVFYPGVVT NNMICAGLDR GQDPCQSDSG GPLVCDETLQ
241 GILSWGVYPC GSAQHPAVYT QICKYMSWIN KVIRSNLocalizationUniProt · AlphaFold · HPA
Whether an antibody against KLK10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.32
- Highest tissue expression
- 136 nTPM
Expression across tissuesHPA
Tissue
- esophagus: 136 nTPM
- vagina: 60 nTPM
- cervix: 46 nTPM
- skin: 20 nTPM
- salivary gland: 18 nTPM
- tonsil: 18 nTPM
Single-cell type
- esophageal apical cells: 2,129 nCPM
- esophageal suprabasal cells: 478 nCPM
- suprabasal keratinocytes: 140 nCPM
- esophageal basal cells: 120 nCPM
- fallopian secretory cells: 87 nCPM
- respiratory secretory cells: 84 nCPM
Immune cell
- neutrophil: 0.2 nTPM
- basophil: 0.1 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
Brain region
- pons: 6.2 nTPM
- midbrain: 4 nTPM
- medulla oblongata: 3.6 nTPM
- hypothalamus: 3.3 nTPM
- cerebellum: 2.8 nTPM
- choroid plexus: 2.5 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.59
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.47
- DepMap mean gene effect
- 0.1
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads KLK10 as an antibody target. Whether an autoantibody or antibody against KLK10 could matter depends on whether native KLK10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
KLK10 is annotated as secreted, so native KLK10 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label KLK10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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