Seroatlas · Human Serome Atlas

KLF18

Kruppel-like factor 18

Also known as: KLF18_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A0U1RQI7
Gene
KLF18
Ensembl
ENSG00000283039
Chromosome
1
Canonical length
1052 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1052 residues, UniProt reviewed canonical sequence.

>A0A0U1RQI7|KLF18
     1  MDSSLLQAIE EIEKFFQHLS ERHTEQAETP DAPEPQNCMP LTAHAEESQH ESTQSKTMPP
    61  LGSTMMTSAC TNIPGTVLTQ DLTMHPLKAL EDLSETYSMG QKVTSFDQVK HTAGSQMTDV
   121  TVTPKSSPTD CQKTTITASN MTISNESSQL NTPSSDQTLN ESQIPALLGD QMKTLSDNQT
   181  LCGDQVTFSS DQTLTDGHTV TSGSDETLSG GQMTTSLDLY GGQMMTSIDN QTLCGEQMTT
   241  SSGNQAFYGR QMTTSTGNQT LCGEQMTTST GNQALYGGQM TTSASNQTLC GEQMTTSTSN
   301  QTLCGEQVMT STGNQALCGG QMTTSTGNQN LYGGQMMTST GNQTLYWGQM MTSTGNQNLC
   361  GEQVMTSTGN QALCGGQMTT STGNQNLYGG QMMTSTGNQT LYWGQMMTST GNQNLCGEQV
   421  MTSTGNQALC GGQMTTSTGN QNLCGEQVMT STSNQTLCGE QTTTSTSNQT LCGEQVTTST
   481  GNQALYGGQM MTSTGNQTLY WGQMMTSTGN QNLCGEQMTT STGNQALYGG QMTTSTSNQT
   541  LCGEQMTTPT SNQTLCGEQV TTSTGNQALY GGQITTSTSN QTLCGEQMTT STSNQTLCGE
   601  QVTTSTGNQA LYGGQMMTST GNQALYGGQM TTSASNQTLC GEQMTTSTSN QTLCEEQVMT
   661  STGNQALCGE QMTTSTGNQA LYGGQMTTST SNQTLCGEQT TTSTSNQTLC GEQVTTSTGN
   721  QALYGGQMMT STGNQTLYWG QMMTSTGNQN LCGEQMTTST GNQALYGGQM TTSTSNQTLC
   781  GEQMTTPTSN QTLCGEQVTT STGNQALYRG QITTSTSNQT LCGEQMTTST SNQTLCGEQV
   841  TTSTGNQALY GGQMMTSTGN QNLYGGQNMT STDNQALYGG QMATYSGNQT LYGDQMLTLQ
   901  VGNMTTLTDD HSLYGGYMMS HQFSSLPYPG FLCFSSSHLI QGQLPKQKTQ SCQFWKNPEV
   961  SRPYVCTYED CKMSYSKACH LRTHMRKHTG EKPYVCDVEG CTWKFARSDE LNRHKKRHTG
  1021  ERPYLCSICS KNFARSDHLK QHAKVHNIRP GL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KLF18 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
0.1 nTPM

Expression across tissuesHPA

Tissue

  • testis: 0.1 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM
  • appendix: 0 nTPM
  • basal ganglia: 0 nTPM

Single-cell type

  • early spermatids: 0.1 nCPM
  • undifferentiated spermatogonia: 0.1 nCPM
  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM
  • adrenal medulla cells: 0 nCPM
  • alveolar cells type 1: 0 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • amygdala: 0 nTPM
  • basal ganglia: 0 nTPM
  • cerebellum: 0 nTPM
  • cerebral cortex: 0 nTPM
  • choroid plexus: 0 nTPM
  • hippocampal formation: 0 nTPM

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KLF18 as an antibody target. Whether an autoantibody or antibody against KLF18 could matter depends on whether native KLF18 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KLF18 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KLF18 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KLF18. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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