Seroatlas · Human Serome Atlas

KLF17

Krueppel-like factor 17

Also known as: FLJ40160, KLF17_HUMAN, Zfp393, ZNF393

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5JT82
Gene: KLF17
Ensembl: ENSG00000171872
Chromosome: 1
Canonical length: 389 aa
Protein class: Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within gamete generation. Predicted to be located in chromatin. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

389 residues, UniProt reviewed canonical sequence.

>Q5JT82|KLF17
     1  MYGRPQAEME QEAGELSRWQ AAHQAAQDNE NSAPILNMSS SSGSSGVHTS WNQGLPSIQH
    61  FPHSAEMLGS PLVSVEAPGQ NVNEGGPQFS MPLPERGMSY CPQATLTPSR MIYCQRMSPP
   121  QQEMTIFSGP QLMPVGEPNI PRVARPFGGN LRMPPNGLPV SASTGIPIMS HTGNPPVPYP
   181  GLSTVPSDET LLGPTVPSTE AQAVLPSMAQ MLPPQDAHDL GMPPAESQSL LVLGSQDSLV
   241  SQPDSQEGPF LPEQPGPAPQ TVEKNSRPQE GTGRRGSSEA RPYCCNYENC GKAYTKRSHL
   301  VSHQRKHTGE RPYSCNWESC SWSFFRSDEL RRHMRVHTRY RPYKCDQCSR EFMRSDHLKQ
   361  HQKTHRPGPS DPQANNNNGE QDSPPAAGP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KLF17 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.62
Highest tissue expression: 8 nTPM

Expression across tissuesHPA

Tissue

testis: 8 nTPM
smooth muscle: 1.1 nTPM
urinary bladder: 1.1 nTPM
endometrium: 0.7 nTPM
adrenal gland: 0.5 nTPM
esophagus: 0.5 nTPM

Single-cell type

early spermatids: 249 nCPM
late spermatids: 62 nCPM
late primary spermatocytes: 60 nCPM
smooth muscle cells: 2.8 nCPM
cardiomyocytes: 1.3 nCPM
oligodendrocyte progenitor cells: 1 nCPM

Immune cell

neutrophil: 0.2 nTPM
basophil: 0.1 nTPM
eosinophil: 0.1 nTPM
naive CD4 T-cell: 0.1 nTPM
T-reg: 0.1 nTPM
classical monocyte: 0 nTPM

Brain region

cerebellum: 0.9 nTPM
thalamus: 0.8 nTPM
amygdala: 0.7 nTPM
cerebral cortex: 0.7 nTPM
white matter: 0.7 nTPM
basal ganglia: 0.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.36
gnomAD pLI: 0
gnomAD missense Z: -0.12
DepMap mean gene effect: -0.2
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KLF17 as an antibody target. Whether an autoantibody or antibody against KLF17 could matter depends on whether native KLF17 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KLF17 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KLF17 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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