Seroatlas · Human Serome Atlas

KLF16

Krueppel-like factor 16

Also known as: BTEB4, DRRF, KLF16_HUMAN, NSLP2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BXK1
Gene: KLF16
Ensembl: ENSG00000129911
Chromosome: 19
Canonical length: 252 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within G protein-coupled dopamine receptor signaling pathway. Predicted to be located in chromatin. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

252 residues, UniProt reviewed canonical sequence.

>Q9BXK1|KLF16
     1  MSAAVACVDY FAADVLMAIS SGAVVHRGRP GPEGAGPAAG LDVRAARREA ASPGTPGPPP
    61  PPPAASGPGP GAAAAPHLLA ASILADLRGG PGAAPGGASP ASSSSAASSP SSGRAPGAAP
   121  SAAAKSHRCP FPDCAKAYYK SSHLKSHLRT HTGERPFACD WQGCDKKFAR SDELARHHRT
   181  HTGEKRFSCP LCSKRFTRSD HLAKHARRHP GFHPDLLRRP GARSTSPSDS LPCSLAGSPA
   241  PSPAPSPAPA GL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KLF16 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 43 nTPM

Expression across tissuesHPA

Tissue

basal ganglia: 43 nTPM
hippocampal formation: 30 nTPM
cerebral cortex: 29 nTPM
amygdala: 25 nTPM
esophagus: 15 nTPM
spleen: 14 nTPM

Single-cell type

late spermatids: 53 nCPM
early spermatids: 52 nCPM
retinal bipolar cells: 44 nCPM
breast hormone-responsive cells: 41 nCPM
pdcs: 37 nCPM
breast secretory cells: 36 nCPM

Immune cell

plasmacytoid DC: 5.2 nTPM
neutrophil: 2.7 nTPM
naive B-cell: 1.6 nTPM
basophil: 1.3 nTPM
eosinophil: 1.3 nTPM
T-reg: 1.3 nTPM

Brain region

basal ganglia: 135 nTPM
cerebral cortex: 106 nTPM
hippocampal formation: 105 nTPM
amygdala: 99 nTPM
hypothalamus: 58 nTPM
thalamus: 55 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.56
gnomAD pLI: 0.2
gnomAD missense Z: 1.5
DepMap mean gene effect: -0.35
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KLF16 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

NFIA

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KLF16 as an antibody target. Whether an autoantibody or antibody against KLF16 could matter depends on whether native KLF16 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KLF16 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KLF16 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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