Seroatlas · Human Serome Atlas

KLF14

Krueppel-like factor 14

Also known as: BTEB5, KLF14_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TD94
Gene: KLF14
Ensembl: ENSG00000266265
Chromosome: 7
Canonical length: 323 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

This intronless gene encodes a member of the Kruppel-like family of transcription factors. The encoded protein functions as a transcriptional co-repressor, and is induced by transforming growth factor-beta (TGF-beta) to repress TGF-beta receptor II gene expression. This gene exhibits imprinted expression from the maternal allele in embryonic and extra-embryonic tissues. [provided by RefSeq, Jul 2013]

Canonical amino-acid sequenceUniProt

323 residues, UniProt reviewed canonical sequence.

>Q8TD94|KLF14
     1  MSAAVACLDY FAAECLVSMS AGAVVHRRPP DPEGAGGAAG SEVGAAPPES ALPGPGPPGP
    61  ASVPQLPQVP APSPGAGGAA PHLLAASVWA DLRGSSGEGS WENSGEAPRA SSGFSDPIPC
   121  SVQTPCSELA PASGAAAVCA PESSSDAPAV PSAPAAPGAP AASGGFSGGA LGAGPAPAAD
   181  QAPRRRSVTP AAKRHQCPFP GCTKAYYKSS HLKSHQRTHT GERPFSCDWL DCDKKFTRSD
   241  ELARHYRTHT GEKRFSCPLC PKQFSRSDHL TKHARRHPTY HPDMIEYRGR RRTPRIDPPL
   301  TSEVESSASG SGPGPAPSFT TCL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KLF14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.63
Highest tissue expression: 1 nTPM

Expression across tissuesHPA

Tissue

adrenal gland: 1 nTPM
testis: 0.8 nTPM
placenta: 0.6 nTPM
adipose tissue: 0.5 nTPM
skeletal muscle: 0.5 nTPM
breast: 0.4 nTPM

Single-cell type

adrenal medulla cells: 11 nCPM
late spermatids: 5.5 nCPM
early spermatids: 4.4 nCPM
neutrophils: 4.3 nCPM
late primary spermatocytes: 2.5 nCPM
smooth muscle cells: 1.9 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hypothalamus: 0.5 nTPM
basal ganglia: 0.1 nTPM
midbrain: 0.1 nTPM
amygdala: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.59
gnomAD pLI: 0.02
gnomAD missense Z: -0.35
DepMap mean gene effect: 0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KLF14 as an antibody target. Whether an autoantibody or antibody against KLF14 could matter depends on whether native KLF14 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KLF14 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KLF14 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...