Seroatlas · Human Serome Atlas

KLF13

Krueppel-like factor 13

Also known as: BTEB3, FKLF-2, KLF13_HUMAN, NSLP1, RFLAT-1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y2Y9
Gene: KLF13
Ensembl: ENSG00000169926
Chromosome: 15
Canonical length: 288 aa
Protein class: Human disease related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

KLF13 belongs to a family of transcription factors that contain 3 classical zinc finger DNA-binding domains consisting of a zinc atom tetrahedrally coordinated by 2 cysteines and 2 histidines (C2H2 motif). These transcription factors bind to GC-rich sequences and related GT and CACCC boxes (Scohy et al., 2000 [PubMed 11087666]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

288 residues, UniProt reviewed canonical sequence.

>Q9Y2Y9|KLF13
     1  MAAAAYVDHF AAECLVSMSS RAVVHGPREG PESRPEGAAV AATPTLPRVE ERRDGKDSAS
    61  LFVVARILAD LNQQAPAPAP AERREGAAAR KARTPCRLPP PAPEPTSPGA EGAAAAPPSP
   121  AWSEPEPEAG LEPEREPGPA GSGEPGLRQR VRRGRSRADL ESPQRKHKCH YAGCEKVYGK
   181  SSHLKAHLRT HTGERPFACS WQDCNKKFAR SDELARHYRT HTGEKKFSCP ICEKRFMRSD
   241  HLTKHARRHA NFHPGMLQRR GGGSRTGSLS DYSRSDASSP TISPASSP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KLF13 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.62
Highest tissue expression: 59 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 59 nTPM
cerebellum: 50 nTPM
thymus: 45 nTPM
pancreas: 42 nTPM
skeletal muscle: 37 nTPM
skin: 32 nTPM

Single-cell type

proximal tubule cells: 96 nCPM
oligodendrocytes: 76 nCPM
renal collecting duct intercalated cells: 67 nCPM
renal connecting tubule cells: 60 nCPM
renal collecting duct principal cells: 55 nCPM
loop of henle epithelial cells: 47 nCPM

Immune cell

memory B-cell: 27 nTPM
naive B-cell: 24 nTPM
T-reg: 21 nTPM
naive CD8 T-cell: 21 nTPM
plasmacytoid DC: 21 nTPM
MAIT T-cell: 14 nTPM

Brain region

white matter: 96 nTPM
cerebellum: 89 nTPM
thalamus: 86 nTPM
cerebral cortex: 82 nTPM
hippocampal formation: 69 nTPM
medulla oblongata: 67 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.93
gnomAD pLI: 0.4
gnomAD missense Z: 2.02
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KLF13 as an antibody target. Whether an autoantibody or antibody against KLF13 could matter depends on whether native KLF13 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KLF13 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KLF13 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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