Seroatlas · Human Serome Atlas

KLF10

Krueppel-like factor 10

Also known as: EGRA, KLF10_HUMAN, TIEG, TIEG1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q13118
Gene: KLF10
Ensembl: ENSG00000155090
Chromosome: 8
Canonical length: 480 aa
Protein class: Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

This gene encodes a member of a family of proteins that feature C2H2-type zinc finger domains. The encoded protein is a transcriptional repressor that acts as an effector of transforming growth factor beta signaling. Activity of this protein may inhibit the growth of cancers, particularly pancreatic cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

Canonical amino-acid sequenceUniProt

480 residues, UniProt reviewed canonical sequence.

>Q13118|KLF10
     1  MLNFGASLQQ TAEERMEMIS ERPKESMYSW NKTAEKSDFE AVEALMSMSC SWKSDFKKYV
    61  ENRPVTPVSD LSEEENLLPG TPDFHTIPAF CLTPPYSPSD FEPSQVSNLM APAPSTVHFK
   121  SLSDTAKPHI AAPFKEEEKS PVSAPKLPKA QATSVIRHTA DAQLCNHQTC PMKAASILNY
   181  QNNSFRRRTH LNVEAARKNI PCAAVSPNRS KCERNTVADV DEKASAALYD FSVPSSETVI
   241  CRSQPAPVSP QQKSVLVSPP AVSAGGVPPM PVICQMVPLP ANNPVVTTVV PSTPPSQPPA
   301  VCPPVVFMGT QVPKGAVMFV VPQPVVQSSK PPVVSPNGTR LSPIAPAPGF SPSAAKVTPQ
   361  IDSSRIRSHI CSHPGCGKTY FKSSHLKAHT RTHTGEKPFS CSWKGCERRF ARSDELSRHR
   421  RTHTGEKKFA CPMCDRRFMR SDHLTKHARR HLSAKKLPNW QMEVSKLNDI ALPPTPAPTQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KLF10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.63
Highest tissue expression: 160 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 160 nTPM
bone marrow: 144 nTPM
pancreas: 119 nTPM
tongue: 115 nTPM
liver: 90 nTPM
skin: 73 nTPM

Single-cell type

epididymal efferent duct absorptive cells: 355 nCPM
endometrial luminal cells: 267 nCPM
smooth muscle cells: 247 nCPM
breast secretory cells: 208 nCPM
neutrophils: 206 nCPM
salivary acinar cells: 204 nCPM

Immune cell

myeloid DC: 57 nTPM
classical monocyte: 53 nTPM
intermediate monocyte: 48 nTPM
total PBMC: 35 nTPM
non-classical monocyte: 26 nTPM
T-reg: 19 nTPM

Brain region

cerebral cortex: 24 nTPM
choroid plexus: 12 nTPM
hippocampal formation: 11 nTPM
basal ganglia: 10 nTPM
midbrain: 9.6 nTPM
hypothalamus: 9.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.87
gnomAD pLI: 0
gnomAD missense Z: 1.39
DepMap mean gene effect: -0.17
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KLF10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KLF10 as an antibody target. Whether an autoantibody or antibody against KLF10 could matter depends on whether native KLF10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KLF10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KLF10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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