KISS1

Protein identityUniProt · HPA

UniProt accession

Q15726

Gene

KISS1

Ensembl

ENSG00000170498

Chromosome

1

Canonical length

138 aa

Protein class

Cancer-related genes, Disease related genes, Human disease related genes, Predicted secreted proteins

Subcellular location

Vesicles

Secretome location

Secreted in female reproductive system

OverviewNCBI Gene

This gene is a metastasis suppressor gene that suppresses metastases of melanomas and breast carcinomas without affecting tumorigenicity. The encoded protein may inhibit chemotaxis and invasion and thereby attenuate metastasis in malignant melanomas. Studies suggest a putative role in the regulation of events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. A protein product of this gene, kisspeptin, stimulates gonadotropin-releasing hormone (GnRH)-induced gonadotropin secretion and regulates the pubertal activation of GnRH neurons. A polymorphism in the terminal exon of this mRNA results in two protein isoforms. An adenosine present at the polymorphic site represents the third position in a stop codon. When the adenosine is absent, a downstream stop codon is utilized and the encoded protein extends for an additional seven amino acid residues. [provided by RefSeq, Jun 2022]

Canonical amino-acid sequenceUniProt

138 residues, UniProt reviewed canonical sequence.

>Q15726|KISS1
     1  MNSLVSWQLL LFLCATHFGE PLEKVASVGN SRPTGQQLES LGLLAPGEQS LPCTERKPAA
    61  TARLSRRGTS LSPPPESSGS PQQPGLSAPH SRQIPAPQGA VLVQREKDLP NYNWNSFGLR
   121  FGKREAAPGN HGRSAGRG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KISS1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.66

Highest tissue expression

220 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about KISS1.

Disease | AllUniProt

Conditions KISS1 is implicated in, by any mechanism.

• Hypogonadotropic hypogonadism 13 with or without anosmia (HH13) MIM:614842

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 73 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Hypogonadotropic hypogonadism 13 with or without anosmia

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.41

gnomAD pLI

0.49

gnomAD missense Z

-0.1

DepMap mean gene effect

-0.15

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cytoskeleton organization
• G protein-coupled receptor signaling pathway
• positive regulation of luteinizing hormone secretion

Molecular functions

• kisspeptin receptor binding

Cellular components

• extracellular region
• extracellular space

Protein domainsUniProt · Pfam · InterPro

• Metastasis-suppressor KiSS-1
• Kisspeptin

KeywordsUniProt

• Amidation
• Cleavage on pair of basic residues
• Hypogonadotropic hypogonadism
• Phosphoprotein
• Secreted
• Signal