Seroatlas · Human Serome Atlas

KIRREL3-AS3

Putative uncharacterized protein KIRREL3-AS3

Also known as: KIAS3_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N7Y1
Gene: KIRREL3-AS3
Canonical length: 241 aa

OverviewNCBI Gene

No narrative summary is available for KIRREL3-AS3 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

241 residues, UniProt reviewed canonical sequence.

>Q8N7Y1|KIRREL3-AS3
     1  MEKRGESLDL GVRCKRGEER DRRPCWKPSR PGAARGGRGL WTVGGGGSPT ETAESQQLGK
    61  PPEFWVSAHP GWLQVSCAHR ASRWDASRWH PLQRFFARRG VRRPNPSVPS PLPKPPVPSA
   121  GSCEPLAPPP TSASGASRSW VTQTLAEAGA YRGCRPAPGS AAGWPRSDRR ARLPRKASKP
   181  CSPALPSLAA CCPQGFLRSG TKRVMCKVLG PGAGVRGTAV ECSEQAGVWA HCRPQLTATF
   241  S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KIRREL3-AS3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.69

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KIRREL3-AS3 as an antibody target. Whether an autoantibody or antibody against KIRREL3-AS3 could matter depends on whether native KIRREL3-AS3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KIRREL3-AS3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KIRREL3-AS3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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