Seroatlas · Human Serome Atlas

KIR3DX1

Putative killer cell immunoglobulin-like receptor-like protein KIR3DX1

Also known as: KI3X1_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H7L2
Gene: KIR3DX1
Canonical length: 352 aa

OverviewNCBI Gene

No narrative summary is available for KIR3DX1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

352 residues, UniProt reviewed canonical sequence.

>Q9H7L2|KIR3DX1
     1  MAPKLITVLC LGFCLNQKIC PHAGAQDKFS LSAWPSPVVP LGGRVTLSCH SHLRFVIWTI
    61  FQTTGTRSHE LHTGLSNNIT ISPVTPEHAG TYRCVGIYKH ASKWSAESNS LKIIVTGLFT
   121  KPSISAHPSS LVHAGARVSL RCHSELAFDE FILYKEGHIQ HSQQLDQGME AGIHYVEAVF
   181  SMGPVTPAHA GAYRCCGCFS HSRYEWSAPS DPLDIVITGK YKKPSLSTQV DPMMRLGEKL
   241  TLFCSSEISF DQYHLFRHGV AHGQWLSGGQ RHREAFQANF SVGRATPVPG GTYRCYGSFN
   301  DSPYKPPVTR CNFTPQETLR VLLCHSQNPP LNLTHLALKD SPATCICSLD SQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KIR3DX1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KIR3DX1 as an antibody target. Whether an autoantibody or antibody against KIR3DX1 could matter depends on whether native KIR3DX1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KIR3DX1 is annotated as secreted, so native KIR3DX1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label KIR3DX1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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