Seroatlas · Human Serome Atlas

KIR3DS1

Killer cell immunoglobulin-like receptor 3DS1

Also known as: KI3S1_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q14943
Gene: KIR3DS1
Canonical length: 382 aa

OverviewNCBI Gene

No narrative summary is available for KIR3DS1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

382 residues, UniProt reviewed canonical sequence.

>Q14943|KIR3DS1
     1  MLLMVVSMAC VGLFLVQRAG PHMGGQDKPF LSAWPSAVVP RGGHVTLRCH YRHRFNNFML
    61  YKEDRIHVPI FHGRIFQEGF NMSPVTTAHA GNYTCRGSHP HSPTGWSAPS NPMVIMVTGN
   121  HRKPSLLAHP GPLVKSGERV ILQCWSDIMF EHFFLHREWI SKDPSRLVGQ IHDGVSKANF
   181  SIGSMMRALA GTYRCYGSVT HTPYQLSAPS DPLDIVVTGL YEKPSLSAQP GPKVQAGESV
   241  TLSCSSRSSY DMYHLSREGG AHERRLPAVR KVNRTFQADF PLGPATHGGT YRCFGSFRHS
   301  PYEWSDPSDP LLVSVTGNPS SSWPSPTEPS SKSGNLRHLH ILIGTSVVKI PFTILLFFLL
   361  HRWCSNKKKC CCNGPRACRE QK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KIR3DS1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.37

OntologyGO

Biological processes

Molecular functions

MHC class I receptor activity

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KIR3DS1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

HLA-F

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KIR3DS1 as an antibody target. Whether an autoantibody or antibody against KIR3DS1 could matter depends on whether native KIR3DS1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KIR3DS1 is annotated at the cell surface, where native KIR3DS1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label KIR3DS1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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