Seroatlas · Human Serome Atlas

KIR2DS4

Killer cell immunoglobulin-like receptor 2DS4

Also known as: KI2S4_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P43632
Gene
KIR2DS4
Canonical length
304 aa
Protein class
Predicted secreted proteins

OverviewNCBI Gene

No narrative summary is available for KIR2DS4 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

304 residues, UniProt reviewed canonical sequence.

>P43632|KIR2DS4
     1  MSLMVIIMAC VGFFLLQGAW PQEGVHRKPS FLALPGHLVK SEETVILQCW SDVMFEHFLL
    61  HREGKFNNTL HLIGEHHDGV SKANFSIGPM MPVLAGTYRC YGSVPHSPYQ LSAPSDPLDM
   121  VIIGLYEKPS LSAQPGPTVQ AGENVTLSCS SRSSYDMYHL SREGEAHERR LPAVRSINGT
   181  FQADFPLGPA THGGTYRCFG SFRDAPYEWS NSSDPLLVSV TGNPSNSWPS PTEPSSKTGN
   241  PRHLHVLIGT SVVKIPFTIL LFFLLHRWCS DKKNAAVMDQ EPAGNRTVNS EDSDEQDHQE
   301  VSYA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KIR2DS4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.4
Highest tissue expression
0 nTPM

Expression across tissuesHPA

Tissue

  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • appendix: 0 nTPM
  • bone marrow: 0 nTPM
  • breast: 0 nTPM
  • cerebral cortex: 0 nTPM

Single-cell type

  • nk-cells: 3.1 nCPM
  • t-cells: 0.1 nCPM
  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM
  • adrenal medulla cells: 0 nCPM
  • alveolar cells type 1: 0 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • amygdala: 0 nTPM
  • basal ganglia: 0 nTPM
  • cerebellum: 0 nTPM
  • cerebral cortex: 0 nTPM
  • choroid plexus: 0 nTPM
  • hippocampal formation: 0 nTPM

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KIR2DS4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KIR2DS4 as an antibody target. Whether an autoantibody or antibody against KIR2DS4 could matter depends on whether native KIR2DS4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KIR2DS4 is annotated at the cell surface, where native KIR2DS4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label KIR2DS4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KIR2DS4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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