Seroatlas · Human Serome Atlas

KIR2DS2

Killer cell immunoglobulin-like receptor 2DS2

Also known as: KI2S2_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P43631
Gene: KIR2DS2
Canonical length: 304 aa

OverviewNCBI Gene

No narrative summary is available for KIR2DS2 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

304 residues, UniProt reviewed canonical sequence.

>P43631|KIR2DS2
     1  MSLMVVSMAC VGFFLLQGAW PHEGVHRKPS LLAHPGPLVK SEETVILQCW SDVRFEHFLL
    61  HREGKYKDTL HLIGEHHDGV SKANFSIGPM MQDLAGTYRC YGSVTHSPYQ LSAPSDPLDI
   121  VITGLYEKPS LSAQPGPTVL AGESVTLSCS SRSSYDMYHL SREGEAHERR FSAGPKVNGT
   181  FQADFPLGPA THGGTYRCFG SFRDSPYEWS NSSDPLLVSV TGNPSNSWPS PTEPSSKTGN
   241  PRHLHVLIGT SVVKIPFTIL LFFLLHRWCS NKKNAAVMDQ EPAGNRTVNS EDSDEQDHQE
   301  VSYA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KIR2DS2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.4

OntologyGO

Biological processes

Molecular functions

transmembrane signaling receptor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KIR2DS2 as an antibody target. Whether an autoantibody or antibody against KIR2DS2 could matter depends on whether native KIR2DS2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KIR2DS2 is annotated at the cell surface, where native KIR2DS2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label KIR2DS2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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