Seroatlas · Human Serome Atlas

KIR2DL5A

Killer cell immunoglobulin-like receptor 2DL5A

Also known as: KI2LA_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N109
Gene: KIR2DL5A
Canonical length: 375 aa

OverviewNCBI Gene

No narrative summary is available for KIR2DL5A in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

375 residues, UniProt reviewed canonical sequence.

>Q8N109|KIR2DL5A
     1  MSLMVISMAC VGFFLLQGAW THEGGQDKPL LSAWPSAVVP RGGHVTLLCR SRLGFTIFSL
    61  YKEDGVPVPE LYNKIFWKSI LMGPVTPAHA GTYRCRGSHP RSPIEWSAPS NPLVIVVTGL
   121  FGKPSLSAQP GPTVRTGENV TLSCSSRSSF DMYHLSREGR AHEPRLPAVP SVNGTFQADF
   181  PLGPATHGGT YTCFGSLHDS PYEWSDPSDP LLVSVTGNSS SSSSSPTEPS SKTGIRRHLH
   241  ILIGTSVAII LFIILFFFLL HCCCSNKKNA AVMDQEPAGD RTVNREDSDD QDPQEVTYAQ
   301  LDHCVFTQTK ITSPSQRPKT PPTDTTMYME LPNAKPRSLS PAHKHHSQAL RGSSRETTAL
   361  SQNRVASSHV PAAGI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KIR2DL5A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.47

OntologyGO

Biological processes

immune response-regulating signaling pathway

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KIR2DL5A as an antibody target. Whether an autoantibody or antibody against KIR2DL5A could matter depends on whether native KIR2DL5A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KIR2DL5A is annotated at the cell surface, where native KIR2DL5A is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label KIR2DL5A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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