Seroatlas · Human Serome Atlas

KIR2DL2

Killer cell immunoglobulin-like receptor 2DL2

Also known as: KI2L2_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P43627
Gene: KIR2DL2
Canonical length: 348 aa

OverviewNCBI Gene

No narrative summary is available for KIR2DL2 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

348 residues, UniProt reviewed canonical sequence.

>P43627|KIR2DL2
     1  MSLMVVSMAC VGFFLLQGAW PHEGVHRKPS LLAHPGRLVK SEETVILQCW SDVRFEHFLL
    61  HREGKFKDTL HLIGEHHDGV SKANFSIGPM MQDLAGTYRC YGSVTHSPYQ LSAPSDPLDI
   121  VITGLYEKPS LSAQPGPTVL AGESVTLSCS SRSSYDMYHL SREGEAHECR FSAGPKVNGT
   181  FQADFPLGPA THGGTYRCFG SFRDSPYEWS NSSDPLLVSV IGNPSNSWPS PTEPSSKTGN
   241  PRHLHILIGT SVVIILFILL FFLLHRWCSN KKNAAVMDQE SAGNRTANSE DSDEQDPQEV
   301  TYTQLNHCVF TQRKITRPSQ RPKTPPTDII VYAELPNAES RSKVVSCP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KIR2DL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.44

OntologyGO

Biological processes

immune response-regulating signaling pathway

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KIR2DL2 as an antibody target. Whether an autoantibody or antibody against KIR2DL2 could matter depends on whether native KIR2DL2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KIR2DL2 is annotated at the cell surface, where native KIR2DL2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label KIR2DL2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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