Seroatlas · Human Serome Atlas

KIAA2013

Uncharacterized protein KIAA2013

Also known as: K2013_HUMAN, MGC33867, RP5-1077B9.1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IYS2
Gene: KIAA2013
Ensembl: ENSG00000116685
Chromosome: 1
Canonical length: 634 aa
Protein class: Predicted membrane proteins
Subcellular location: Golgi apparatus,Cytosol

OverviewNCBI Gene

Located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

634 residues, UniProt reviewed canonical sequence.

>Q8IYS2|KIAA2013
     1  MWLQQRLKGL PGLLSSSWAR RLLCLLGLLL LLLWFGGSGA RRAAGGLHLL PWSRGEPGAA
    61  EPSACLEAAT RAWRGLRERG EVVPLGPGVP ALVANGFLAL DVAANRLWVT PGEREPAVAP
   121  DFVPFVQLRP LSALAEAGEA VLLLREGLLR RVRCLQLGSP GPGPVAAGPG PASVSGLAAG
   181  SGRDCVLLQE DFLAHRGRPH VYLQRIQLNN PTERVAALQT VGPTAGPAPK AFTSTLEKVG
   241  DHQFLLYSGR SPPTPTGLVH LVVVAAKKLV NRLQVAPKTQ LDETVLWVVH VSGPINPQVL
   301  KSKAAKELKA LQDLARKEML ELLDMPAAEL LQDHQLLWAQ LFSPGVEMKK ITDTHTPSGL
   361  TVNLTLYYML SCSPAPLLSP SLSHRERDQM ESTLNYEDHC FSGHATMHAE NLWPGRLSSV
   421  QQILQLSDLW RLTLQKRGCK GLVKVGAPGI LQGMVLSFGG LQFTENHLQF QADPDVLHNS
   481  YALHGIRYKN DHINLAVLAD AEGKPYLHVS VESRGQPVKI YACKAGCLDE PVELTSAPTG
   541  HTFSVMVTQP ITPLLYISTD LTHLQDLRHT LHLKAILAHD EHMAQQDPGL PFLFWFSVAS
   601  LITLFHLFLF KLIYNEYCGP GAKPLFRSKE DPSV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KIAA2013 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 62 nTPM

Expression across tissuesHPA

Tissue

duodenum: 62 nTPM
small intestine: 58 nTPM
liver: 57 nTPM
skeletal muscle: 50 nTPM
blood vessel: 46 nTPM
colon: 41 nTPM

Single-cell type

epididymal principal cells: 146 nCPM
enterocytes: 128 nCPM
colonocytes: 95 nCPM
hepatocytes: 89 nCPM
neutrophils: 79 nCPM
late spermatids: 66 nCPM

Immune cell

neutrophil: 11 nTPM
plasmacytoid DC: 8.5 nTPM
naive B-cell: 6.8 nTPM
T-reg: 5.5 nTPM
memory B-cell: 5.2 nTPM
eosinophil: 5.1 nTPM

Brain region

medulla oblongata: 55 nTPM
white matter: 52 nTPM
midbrain: 47 nTPM
basal ganglia: 47 nTPM
pons: 46 nTPM
spinal cord: 46 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.76
gnomAD pLI: 0.01
gnomAD missense Z: 1.83
DepMap mean gene effect: -0.23
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

Uncharacterized protein KIAA2013-like
Uncharacterized conserved protein (DUF2152)

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KIAA2013 as an antibody target. Whether an autoantibody or antibody against KIAA2013 could matter depends on whether native KIAA2013 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KIAA2013 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KIAA2013 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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