Seroatlas · Human Serome Atlas

KIAA2012

Uncharacterized protein KIAA2012

Also known as: K2012_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q0VF49
Gene: KIAA2012
Canonical length: 1180 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for KIAA2012 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

1180 residues, UniProt reviewed canonical sequence.

>Q0VF49|KIAA2012
     1  MFTLSLLSRG HGKLGQDKQK LEVYFEPEDY LNWRSPEDYV PVSKPQDKNN ASQHSWSLFL
    61  PKTFSTRKGA LILYSEGFAI SAWTPKERRK GPYCPRGPWR KLDLELHTLQ DLKEAILAYG
   121  RQQGEQDRAW QPYLHFRSQL ESQAQRQIQP GHSAKRYLRG LLRTWPPDAM YRLWCAGYIK
   181  DSVLLQDSQL NVPKKLRPQQ DLSGVPPKYH LLPVFPSFWI QQGKSFEQRQ QGLDEGEAGA
   241  AGHVDQGPLA KNHGSQGTRL PPRRKQPWQE DETQAEDTSI ENHLCLYASK ESYNEKTQQT
   301  SRKAFGHGRI DHSWLPSDKS HITFCGGAFP NRKADLSDKQ RNVKLHKARS SHLLQVLPAE
   361  RSLFPPVASA TGSRIITPGE VKKKKAPKAL KLPPISEEPP RVLEPLKSQF KANEPPTELF
   421  ILPVEIHYHT KQPPKEKAHR RGAPHPESEP ESSEESTPVW RPPLKHASLE TPWELTVHLP
   481  VDASRDTLSP QGSSSLPPAS LGNLTLKGSK ARHTRVHSQG KGVWKGDDDA PPHDVAPPLD
   541  LLPPIKGKKS PESQKGVDSP RTSDHNSPPS LPNMRVPRRA LPAAQEDSSD PTLGHFLLGP
   601  DGEKVCLSLP GHTQTEALPS GKAYESVNSN ISHEEEGPSS QHFLKANTEP RANLHMNLYE
   661  TSPLTQTTEK QGAQQSLEAA AQKTGEPQSC INKALICSNR KEFYTRKLHI DMTPFLKESG
   721  NALDYQEEAG RPLRETHHND QDPEPRSMTL DSPRASRTEH IQTPEADIVQ KVGRDYDVHH
   781  LHRGLLGYGP ESPERLSAVY TSLLPREREG KAEPRLFSQE TSANISHERD LINEAKRKEK
   841  PKKDKTKGPK SEREGKVYGQ AEAAIGKSKD SKAKKKLEKK TRPQRKRTQK ERNLEIAAEL
   901  SGPDVSYEET EDTSNRGSFA SDSFVEDPWL SPKYDAQESQ VSLDGRSSPS QIATVTGNME
   961  SKEERRCEDP SKALLTKREQ EKASWDRLRA ERAEMRWLEV EKKRREQEEQ RQLQQEQLER
  1021  AKKMEEELEL EQQRRTEEIR LRKQRLQEEQ QRQEEEERKQ QLRLKAAQER ARQQQEEFRR
  1081  KLRELQRKKQ QEEAERAEAE KQRQEELEMQ LEEEQKHLME MAEEERLEYQ RRKQEAEEKA
  1141  RLEAEERRQK EEEAARLALE EATKQAQEQA RYWIFGQQLP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KIAA2012 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.65
Highest tissue expression: 8.7 nTPM

Expression across tissuesHPA

Tissue

fallopian tube: 8.7 nTPM
choroid plexus: 1.4 nTPM
hippocampal formation: 1.2 nTPM
basal ganglia: 1.1 nTPM
hypothalamus: 1.1 nTPM
testis: 0.9 nTPM

Single-cell type

ependymal cells: 770 nCPM
respiratory ciliated cells: 496 nCPM
fallopian tube ciliated cells: 290 nCPM
epididymal efferent duct ciliated cells: 171 nCPM
corticotrophs: 99 nCPM
endometrial ciliated cells: 78 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

midbrain: 17 nTPM
medulla oblongata: 14 nTPM
spinal cord: 13 nTPM
choroid plexus: 8.5 nTPM
hippocampal formation: 6.1 nTPM
basal ganglia: 6 nTPM

Protein domainsUniProt · Pfam · InterPro

Protein of unknown function DUF4670
Domain of unknown function (DUF4670)

KeywordsUniProt

Coiled coil

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KIAA2012 as an antibody target. Whether an autoantibody or antibody against KIAA2012 could matter depends on whether native KIAA2012 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KIAA2012 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KIAA2012 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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