Seroatlas · Human Serome Atlas

KIAA1958

Uncharacterized protein KIAA1958

Also known as: FLJ39294, K1958_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N8K9
Gene: KIAA1958
Ensembl: ENSG00000165185
Chromosome: 9
Canonical length: 716 aa
Protein class: Predicted intracellular proteins
Subcellular location: Plasma membrane,Cytosol

OverviewNCBI Gene

No narrative summary is available for KIAA1958 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

716 residues, UniProt reviewed canonical sequence.

>Q8N8K9|KIAA1958
     1  MEDCLHTSSE NLSKLVSWAH SHGTICSLIP NLKHLLSEGS HGNLTAMWGC SAGHAYHWPL
    61  TATCRAGSQE RVCFQDNRSF NSDSPSIIGV PSETQTSPVE RYPGRPVKAK LDCNRTRDSC
   121  DFSYCSEPSE LDETVEEYED ENTLFDMVCE SSVTDEDSDF EPQTQRPQSI ARKRPGVVPS
   181  SLHSSSQTQM VDECSNDVII KKIKQEIPED YYIVANAELT GGVDGPALSL TQMAKPKPQT
   241  HAGPSCVGSA KLIPHVTSAI STELDPHGMS ASPSVISRPI VQKTARVSLA SPNRGPPGTH
   301  GTNQQVAMQM PVSTSHPNKQ ISIPLSALQL PGQDEQVASE EFLSHLPSQV SSCEVALSPS
   361  VNTEPEVSSS QQQPPVAPAI TTEATAQCIP AYSTKLNKFP VFNINDDLND LCTSAVSPNT
   421  TKATRYALNV WRYWCMTNGL KDHTDITKIP AVKLNELLEN FYVTVKKSDG SDFLATSLHA
   481  IRRGLDRILK NAGVGFSITS STFSSSTKKL KEKLWVLSKA GMSGARSRNI VYFSLSDEEE
   541  MWQAGCLGDD SPITLLSTVV KYNSQYLNMR TLQEHADLMY GDIELLKDPQ NQPYFARTDS
   601  VKRESRSGST RVCHGKIYHE HSRGHKQCPY CLLYKYMYIH RPPTQMEAKS PFYLTARKEA
   661  TDMGSVWYEE QRMGLRSLRG IVPNLAKKVK LENCENFTFV SFTQVSRRLG SHSCCQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KIAA1958 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 9.3 nTPM

Expression across tissuesHPA

Tissue

retina: 9.3 nTPM
ovary: 7 nTPM
adrenal gland: 6.2 nTPM
kidney: 5.4 nTPM
testis: 5.4 nTPM
bone marrow: 4.6 nTPM

Single-cell type

adrenal cortex cells: 735 nCPM
sertoli cells: 704 nCPM
distal convoluted tubule cells: 384 nCPM
bergmann glia: 374 nCPM
astrocytes: 309 nCPM
gastric chief cells: 276 nCPM

Immune cell

classical monocyte: 0.7 nTPM
naive CD8 T-cell: 0.6 nTPM
neutrophil: 0.6 nTPM
NK-cell: 0.6 nTPM
plasmacytoid DC: 0.6 nTPM
gdT-cell: 0.5 nTPM

Brain region

white matter: 43 nTPM
thalamus: 37 nTPM
basal ganglia: 36 nTPM
cerebellum: 33 nTPM
midbrain: 33 nTPM
medulla oblongata: 32 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.64
gnomAD pLI: 0.01
gnomAD missense Z: 1.24
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KIAA1958 as an antibody target. Whether an autoantibody or antibody against KIAA1958 could matter depends on whether native KIAA1958 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KIAA1958 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KIAA1958 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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