Seroatlas · Human Serome Atlas

KIAA1755

Uncharacterized protein KIAA1755

Also known as: K1755_HUMAN, quo, RP5-1054A22.3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5JYT7
Gene: KIAA1755
Ensembl: ENSG00000149633
Chromosome: 20
Canonical length: 1200 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoli,Golgi apparatus,Vesicles

OverviewNCBI Gene

Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in axon guidance. Predicted to be active in cytoplasm and plasma membrane. Predicted to be extrinsic component of membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1200 residues, UniProt reviewed canonical sequence.

>Q5JYT7|KIAA1755
     1  MDPPSLDTAI QHALAGLYPP FEATAPTVLG QVFRLLDSGF QGDGLSFLLD FLIPAKRLCE
    61  QVREAACAPY SHCLFLHEGW PLCLRDEVVV HLAPLNPLLL RQGDFYLQVE PQEEQSVCIM
   121  IKCLSLDLCT VDKKPVPEPA YPILFTQEWL EAINSDFEGN PLHNCLVASE NGIAPVPWTK
   181  ITSPEFVDDR PQVVNALCQA WGPLPLEALD LSSPQELHQA SSPDNQVLPA QSLAKGKGRT
   241  YGSKYPGLIK VEQARCGEVA FRMDEVVSQD FEGDYVALLG FSQESRGESP SREAGTSSGC
   301  TSGALEEIAG TKETPLFQKI LPLSEANEGP SLGNRACTKP ESSEERPYNL GFRRKVNLKA
   361  PTHNSERPPQ GSYMNVLEDA LDCASGLRAG VSQEPAASKM QGPLGNPENM VQLRPGPRQA
   421  SSPRLSPASP AAAASETKIE VKTKERNGRL PKPMPCPSRN TSSPEPPTPG LKFSFLRGQR
   481  QPSVTPEKAS LQHNGPWKVL CSLYSPKPNR AKSLGKAGTT QTKTSGPATA PSPLTEEKAA
   541  LPEASAGSPE RGPTLEEEPP GPEPRIGALG VKVFRSRIAC LPGGRDRAGR PLLLVSTTEG
   601  AWEAPWCTVS EVTKLLSYLC TIPRPEDKAK GLAVLIDARR QPPQPGLVSA LQATQAQVPA
   661  SIRAILFLGE KEAALQLQTL PDVQVEVLTS LKALSHHVDP SQLPAVLEGP FPYCHTEWVH
   721  FFQKLDPFLA DLHQASSLLQ ASIEEFEKAD PPGGMQEATR CLSKSKELME AVLRDPGLLG
   781  LQREGGATLA RLQHDASRLD FSPDVRSHLA AATALYSLVD EQLHVLVTAS NSLLGKLELR
   841  VRLGRLEAAI HQVSDWMEQE GRRCLQSLTP KDGSLETVEK AHAEFENFFL QAAAQYRRGL
   901  ELSKQAAQLG ATARGAGEAE RAEFPELAAF ASTQRAFQAE LTHFYMAAER QRTDLETLLH
   961  LHRFCKRMTW FHMDCQDLMA QLRLDKTSRV SPGDQRRLHR YLQRLASEFP AEKLAAVGLQ
  1021  VASLSRAGLG QELWEEARIR HEEIRMLLEK ALTHSSCPEA PAAHSARPER RGVAAKGQGV
  1081  SVEVTSKGRW DQPPLDSLGM DHLPKSYWPP GPPRGEQNRT FQAGSPPQEA GQAAEAEDGK
  1141  GSHKLPDPAR EHLLATTFFR QQPPRQSQVP RLTGGSFSSE GTDSQTSLED SPQTSPLASL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KIAA1755 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 18 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 18 nTPM
gallbladder: 15 nTPM
endometrium: 14 nTPM
smooth muscle: 14 nTPM
spinal cord: 13 nTPM
cervix: 12 nTPM

Single-cell type

oligodendrocytes: 191 nCPM
bergmann glia: 132 nCPM
astrocytes: 123 nCPM
fibro-adipogenic progenitors: 89 nCPM
fibroblasts: 42 nCPM
ependymal cells: 41 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

white matter: 301 nTPM
basal ganglia: 267 nTPM
thalamus: 245 nTPM
hypothalamus: 220 nTPM
midbrain: 218 nTPM
medulla oblongata: 215 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.03
gnomAD pLI: 0
gnomAD missense Z: -0.32
DepMap mean gene effect: 0.11
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

axon guidance

Molecular functions

guanyl-nucleotide exchange factor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

Rho GEF and signaling-related domain-containing protein

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KIAA1755 as an antibody target. Whether an autoantibody or antibody against KIAA1755 could matter depends on whether native KIAA1755 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KIAA1755 is annotated at the cell surface, where native KIAA1755 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label KIAA1755 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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