Seroatlas · Human Serome Atlas

KIAA1614

Uncharacterized protein KIAA1614

Also known as: K1614_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5VZ46
Gene: KIAA1614
Ensembl: ENSG00000135835
Chromosome: 1
Canonical length: 1190 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear membrane,Vesicles

OverviewNCBI Gene

Predicted to be involved in centrosome cycle; establishment or maintenance of cell polarity; and regulation of cellular localization. Predicted to be active in apical plasma membrane; cell cortex; and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1190 residues, UniProt reviewed canonical sequence.

>Q5VZ46|KIAA1614
     1  MEGTEAAAAK PAGGSPQGPK TGSGTASPVE GTSAVEWSGP EPQLDNGHPP RPWPCPQENR
    61  TSSLMAPQPP RVWGVQLQGP SVLESKVRAL KEKMTVAKQG VSPCSASQEW SSPKKPQCRR
   121  GKAGRAGTPS EGSFLPGAVV APRTQNLPDG QLDGSINEEQ PARDGGPRLP RPPAPGREYC
   181  NRGSPWPPEA EWTLPDHDRG PLLGPSSLQQ SPIHGVTPGR PGGPGHCNKI IHIPSPRTGR
   241  SYPFPDGVVT EADLDSTSLT SEEVFVPRTA LLGERWRAGD LEALGAGSSV LSLSDRVERN
   301  RLLLQEMLNV SGQSPRKVGT PAWTPSWDTA APERPVGDVD WASGTSLQDS GQNRTVGPNP
   361  EPVLSPRHEE ATHLLQRARM KARTRPLRAS HDIVPTITQG SRDGHRSPAR DPRTTPACRD
   421  SLQNGHTSDS SSGESSGGHR PRRGPSPSHV RFEDESAREA EFRHLERLQQ RQRQVLSTVL
   481  QAADQGPLRS KPDLADYING APRLRDAGQG TFHRLVGSLD RRGHPAPPAP GSERRCQACG
   541  SCIDDPRPAQ GKAPPVPRTL QELQAACGME RVLGGLSSPL RLLPAEPRLH MEWIRETHIG
   601  DTVCPAEVDS ALDSTDNSDN CRTDSEEAGT SQAGWACGRT QGSSPRLRLR GSRPRGHRWS
   661  KKAEAELPWG LQAQQHLPRA DDVEVENEVK EGRGHTPEGT LFLREDAKPP DLELKRVSLG
   721  PQWQPGPGLG SHQPHPLDSR TPCRTAYATT APMTPESSGP GGQAQVTESH ESLEIVSPSS
   781  LQQSHAEPSA PHQAWQPTAS LCPEGWAPTP PPSRKTTSPV SHRKAALAGL LRLGDQTEPV
   841  GIPRPPSRSA VLRTCELPPS QTQPSRPQVR HPLLALSTNN CNNSAPRGLQ EPYGGAVHEG
   901  RVERGPCSRE PEPPLENSRD GGPQGFLGSA DVATINSTGI TLSLSSEESE SSKESEGSLQ
   961  RTGSGSGGHV LSRASAGAGT GPGSPSAAPL DQNKKRSSSI ASTLGLKKLF SALGQSSRPK
  1021  LGKSRSYSVE QLQPAPPGLT SQSRAPSLQS LHPVSPSHQR RKAASFQNLH SLLSSKGNRS
  1081  SLYLVAGPGD HSAAGRPAKT SPRRALSVED VGAPSLARTV GRLVEVFPDG TSQLQLQRSP
  1141  GGTFGFCVAS GNGRPDSGMP SPLPQPHGWG GLSKQGRAFW LWSEAFLVFG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KIAA1614 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.7
Highest tissue expression: 27 nTPM

Expression across tissuesHPA

Tissue

retina: 27 nTPM
cerebellum: 18 nTPM
colon: 7.9 nTPM
endometrium: 7.9 nTPM
urinary bladder: 7.6 nTPM
heart muscle: 7.4 nTPM

Single-cell type

rod photoreceptor cells: 139 nCPM
cone photoreceptor cells: 95 nCPM
retinal bipolar cells: 77 nCPM
retinal pigment epithelial cells: 47 nCPM
retinal ganglion cells: 35 nCPM
adrenal medulla cells: 32 nCPM

Immune cell

basophil: 1 nTPM
eosinophil: 0.3 nTPM
classical monocyte: 0.1 nTPM
memory B-cell: 0.1 nTPM
myeloid DC: 0.1 nTPM
naive CD4 T-cell: 0.1 nTPM

Brain region

cerebellum: 33 nTPM
cerebral cortex: 13 nTPM
white matter: 12 nTPM
hippocampal formation: 11 nTPM
choroid plexus: 11 nTPM
thalamus: 9.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1
gnomAD pLI: 0
gnomAD missense Z: 0.53
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KIAA1614 as an antibody target. Whether an autoantibody or antibody against KIAA1614 could matter depends on whether native KIAA1614 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KIAA1614 is annotated at the cell surface, where native KIAA1614 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label KIAA1614 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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