Seroatlas · Human Serome Atlas

KIAA1549L

UPF0606 protein KIAA1549L

Also known as: C11orf41, C11orf69, G2, K154L_HUMAN, MGC34830

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZVL6
Gene: KIAA1549L
Ensembl: ENSG00000110427
Chromosome: 11
Canonical length: 1849 aa
Protein class: Predicted membrane proteins
Subcellular location: Nucleoplasm,Vesicles

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1849 residues, UniProt reviewed canonical sequence.

>Q6ZVL6|KIAA1549L
     1  MDHTASQNAQ DLIGIPHLGV SGSSTKWHSE LSPTEGPHSA GSSTPGFLSP MAELSHPSPP
    61  PPALGSLLQL PDGSPSWSML EVASGPASTQ QIKAGVPGRV HNGVSLPTFK NTETATHEAE
   121  PPLFQTAESG AIEMTSRKLA SATANDSANP LHLSAAPENS RGPALSAEHT SSLVPSLHIT
   181  TLGQEQAILS GAVPASPSTG TADFPSILTF LQPTENHASP SPVPEMPTLP AEGSDGSPPA
   241  TRDLLLSSKV PNLLSTSWTF PRWKKDSVTA ILGKNEEANV TIPLQAFPRK EVLSLHTVNG
   301  FVSDFSTGSV SSPIITAPRT NPLPSGPPLP SILSIQATQT VFPSLGFSST KPEAYAAAVD
   361  HSGLPASASK QVRASPSSMD VYDSLTIGDM KKPATTDVFW SSLSAETGSL STESIISGLQ
   421  QQTNYDLNGH TISTTSWETH LAPTAPPNGL TSAADAIKSQ DFKDTAGHSV TAEGFSIQDL
   481  VLGTSIEQPV QQSDMTMVGS HIDLWPTSNN NHSRDFQTAE VAYYSPTTRH SVSHPQLQLP
   541  NQPAHPLLLT SPGPTSTGSL QEMLSDGTDT GSEISSDINS SPERNASTPF QNILGYHSAA
   601  ESSISTSVFP RTSSRVLRAS QHPKKWTADT VSSKVQPTAA AAVTLFLRKS SPPALSAALV
   661  AKGTSSSPLA VASGPAKSSS MTTLAKNVTN KAASGPKRTP GAVHTAFPFT PTYMYARTGH
   721  TTSTHTAMQG NMDTASGLLS TTYLPRKPQA MHTGLPNPTN LEMPRASTPR PLTVTAALTS
   781  ITASVKATRL PPLRAENTDA VLPAASAAVV TTGKMASNLE CQMSSKLLVK TVLFLTQRRV
   841  QISESLKFSI AKGLTQALRK AFHQNDVSAH VDILEYSHNV TVGYYATKGK LVYLPAVVIE
   901  MLGVYGVSNV TADLKQHTPH LQSVAVLASP WNPQPAGYFQ LKTVLQFVSQ ADNIQSCKFA
   961  QTMEQRLQKA FQDAERKVLN TKSNLTIQIV STSNASQAVT LVYVVGNQST FLNGTVASSL
  1021  LSQLSAELVG FYLTYPPLTI AEPLEYPNLD ISETTRDYWV ITVLQGVDNS LVGLHNQSFA
  1081  RVMEQRLAQL FMMSQQQGRR FKRATTLGSY TVQMVKMQRV PGPKDPAELT YYTLYNGKPL
  1141  LGTAAAKILS TIDSQRMALT LHHVVLLQAD PVVKNPPNNL WIIAAVLAPI AVVTVIIIII
  1201  TAVLCRKNKN DFKPDTMINL PQRAKPVQGF DYAKQHLGQQ GADEEVIPVT QETVVLPLPI
  1261  RDAPQERDVA QDGSTIKTAK STETRKSRSP SENGSVISNE SGKPSSGRRS PQNVMAQQKV
  1321  TKEEARKRNV PASDEEEGAV LFDNSSKVAA EPFDTSSGSV QLIAIKPTAL PMVPPTSDRS
  1381  QESSAVLNGE VNKALKQKSD IEHYRNKLRL KAKRKGYYDF PAVETSKGLT ERKKMYEKAP
  1441  KEMEHVLDPD SELCAPFTES KNRQQMKNSV YRSRQSLNSP SPGETEMDLL VTRERPRRGI
  1501  RNSGYDTEPE IIEETNIDRV PEPRGYSRSR QVKGHSETST LSSQPSIDEV RQQMHMLLEE
  1561  AFSLASAGHA GQSRHQEAYG SAQHLPYSEV VTSAPGTMTR PRAGVQWVPT YRPEMYQYSL
  1621  PRPAYRFSQL PEMVMGSPPP PVPPRTGPVA VASLRRSTSD IGSKTRMAES TGPEPAQLHD
  1681  SASFTQMSRG PVSVTQLDQS ALNYSGNTVP AVFAIPAANR PGFTGYFIPT PPSSYRNQAW
  1741  MSYAGENELP SQWADSVPLP GYIEAYPRSR YPQSSPSRLP RQYSQPANLH PSLEQAPAPS
  1801  TAASQQSLAE NDPSDAPLTN ISTAALVKAI REEVAKLAKK QTDMFEFQV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KIAA1549L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 31 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 31 nTPM
cerebral cortex: 21 nTPM
cerebellum: 11 nTPM
basal ganglia: 7.2 nTPM
hippocampal formation: 6 nTPM
amygdala: 5.6 nTPM

Single-cell type

brain inhibitory neurons: 297 nCPM
brain excitatory neurons: 284 nCPM
bergmann glia: 278 nCPM
melanocytes: 219 nCPM
ependymal cells: 158 nCPM
other brain neurons: 156 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 105 nTPM
basal ganglia: 75 nTPM
white matter: 71 nTPM
hippocampal formation: 45 nTPM
amygdala: 37 nTPM
thalamus: 36 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.5
gnomAD pLI: 0
gnomAD missense Z: 1.3
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KIAA1549L as an antibody target. Whether an autoantibody or antibody against KIAA1549L could matter depends on whether native KIAA1549L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KIAA1549L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KIAA1549L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...