Seroatlas · Human Serome Atlas

KIAA1328

Protein hinderin

Also known as: K1328_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q86T90
Gene
KIAA1328
Ensembl
ENSG00000150477
Chromosome
18
Canonical length
577 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nuclear speckles,Vesicles,Lipid droplets,Plasma membrane

OverviewNCBI Gene

No narrative summary is available for KIAA1328 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

577 residues, UniProt reviewed canonical sequence.

>Q86T90|KIAA1328
     1  MADVAGPSRP SAAAFWSRDF SDEEQSVVYV PGISAEGNVR SRHKLMSPKA DVKLKTSRVT
    61  DASISMESLK GTGDSVDEQN SCRGEIKSAS LKDLCLEDKR RIANLIKELA RVSEEKEVTE
   121  ERLKAEQESF EKKIRQLEEQ NELIIKEREA LQLQYRECQE LLSLYQKYLS EQQEKLTMSL
   181  SELGAARMQE QQVSSRKSTL QCSSVELDGS YLSIARPQTY YQTKQRPKSA VQDSASESLI
   241  AFRNNSLKPV TLHHPKDDLD KIPSETTTCN CESPGRKPAV PTEKMPQEEL HMKECPHLKP
   301  TPSQCCGHRL AADRVHDSHP TNMTPQHPKT HPESCSYCRL SWASLVHGGG ALQPIETLKK
   361  QISEDRKQQL MLQKMELEIE KERLQHLLAQ QETKLLLKQQ QLHQSRLDYN CLLKSNCDGW
   421  LLGTSSSIKK HQDPPNSGEN RKERKTVGFH SHMKDDAQWS CQKKDTCRPQ RGTVTGVRKD
   481  ASTSPMPTGS LKDFVTTASP SLQHTTSRYE TSLLDLVQSL SPNSAPKPQR YPSREAGAWN
   541  HGTFRLSPLK STRKKMGMHR TPEELEENQI LEDIFFI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KIAA1328 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.64
Highest tissue expression
20 nTPM

Expression across tissuesHPA

Tissue

  • retina: 20 nTPM
  • bone marrow: 14 nTPM
  • testis: 12 nTPM
  • skin: 8.1 nTPM
  • ovary: 7.1 nTPM
  • skeletal muscle: 6.8 nTPM

Single-cell type

  • choroid plexus epithelial cells: 630 nCPM
  • renal collecting duct intercalated cells: 351 nCPM
  • fibro-adipogenic progenitors: 283 nCPM
  • lactotrophs: 269 nCPM
  • adrenal medulla cells: 255 nCPM
  • thyrotrophs: 255 nCPM

Immune cell

  • basophil: 20 nTPM
  • naive B-cell: 9.6 nTPM
  • eosinophil: 8.5 nTPM
  • neutrophil: 8.5 nTPM
  • MAIT T-cell: 8.3 nTPM
  • T-reg: 8.3 nTPM

Brain region

  • white matter: 225 nTPM
  • cerebral cortex: 210 nTPM
  • cerebellum: 201 nTPM
  • amygdala: 179 nTPM
  • choroid plexus: 174 nTPM
  • basal ganglia: 173 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.93
gnomAD pLI
0
gnomAD missense Z
0.67
DepMap mean gene effect
-0.11
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

  • Protein hinderin
  • Uncharacterised protein KIAA1328

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KIAA1328 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KIAA1328 as an antibody target. Whether an autoantibody or antibody against KIAA1328 could matter depends on whether native KIAA1328 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KIAA1328 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KIAA1328 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KIAA1328. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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