Seroatlas · Human Serome Atlas

KIAA1210

Acrosomal protein KIAA1210

Also known as: K1210_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9ULL0
Gene: KIAA1210
Ensembl: ENSG00000250423
Chromosome: X
Canonical length: 1709 aa
Protein class: Predicted intracellular proteins
Subcellular location: Golgi apparatus,Vesicles

OverviewNCBI Gene

Predicted to be located in acrosomal vesicle and basal ectoplasmic specialization. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1709 residues, UniProt reviewed canonical sequence.

>Q9ULL0|KIAA1210
     1  MRAGWTPRGF SAFHASLLPG RHPYLAHLGP RDRGARIGSR AYSQGCCSCL WLTYKGKKEG
    61  STKGELGPAA VTDLEIPSYS RGFLPCTPRF PTTWCRGPGC FCGTAVIAGN LGDLARIVGP
   121  SHHASQLLLL QEQDSGNHPT MAESLSEISD SLDVLEAGDE GKKKCKFKAL KSFFVKKKEK
   181  EAEDTQEEEM LELSLSSSNI NISSLQPVRE NQPTKARAKS SMGSKALSHD SIFMLGPEPE
   241  RSASKMFPSM DPQRGRPQQR SHISRTLPKP RSKVPGVVSG AMSGAVLQNV PTSAVWVAGP
   301  KITENPPSRR RRLSIIPPVI QPEIISKNLV EISLDDESPK NPQKKALPHK SLTATQSFSE
   361  LSSGPDCSQS LTAFATLAST SSTQLPIGFS TPATTQGCLD SSAARHKMTL NPRKQKKNLQ
   421  VIIRGLPVWF SHFQGILEGS LQCVTQTLET PNLDEPLPVE PKEEEPNLPL VSEEEKSITK
   481  PKEINEKKLG MDSADSSSQK QNNKTEMYDK KTTDQAPNTD ASRSQGYPMS AAYGRRWRRK
   541  GASVSGLSGC EFKGRSLKQS SEGYGLGDRA GSSPTNKTAR NVPFSHLSLE KDNMEQPTTS
   601  QPETTTPQGL LSDKDDMGRR NAGIDFGSRK ASAAQPIPEN MDNSMVSDPQ PYHEDAASGA
   661  EKTEARASLS LMVESLSTTQ EEAILSVAAE AQVFMNPSHI QLEDQEAFSF DLQKAQSKME
   721  SAQDVQTICK EKPSGNVHQT FTASVLGMTS TTAKGDVYAK TLPPRSLFQS SRKPDAEEVS
   781  SDSENIPEEG DGSEELAHGH SSQSLGKFED EQEVFSESKS FVEDLSSSEE ELDLRCLSQA
   841  LEEPEDAEVF TESSSYVEKY NTSDDCSSSE EDLPLRHPAQ ALGKPKNQQE VSSASNNTPE
   901  EQNDFMQQLP SRCPSQPIMN PTVQQQVPTS SVGTSIKQSD SVEPIPPRHP FQPWVNPKVE
   961  QEVSSSPKSM AVEESISMKP LPPKLLCQPL MNPKVQQNMF SGSEDIAVER VISVEPLLPR
  1021  YSPQSLTDPQ IRQISESTAV EEGTYVEPLP PRCLSQPSER PKFLDSMSTS AEWSSPVAPT
  1081  PSKYTSPPWV TPKFEELYQL SAHPESTTVE EDISKEQLLP RHLSQLTVGN KVQQLSSNFE
  1141  RAAIEADISG SPLPPQYATQ FLKRSKVQEM TSRLEKMAVE GTSNKSPIPR RPTQSFVKFM
  1201  AQQIFSESSA LKRGSDVAPL PPNLPSKSLS KPEVKHQVFS DSGSANPKGG ISSKMLPMKH
  1261  PLQSLGRPED PQKVFSYSER APGKCSSFKE QLSPRQLSQA LRKPEYEQKV SPVSASSPKE
  1321  WRNSKKQLPP KHSSQASDRS KFQPQMSSKG PVNVPVKQSS GEKHLPSSSP FQQQVHSSSV
  1381  NAAARRSVFE SNSDNWFLGR DEAFAIKTKK FSQGSKNPIK SIPAPATKPG KFTIAPVRQT
  1441  STSGGIYSKK EDLESGDGNN NQHANLSNQD DVEKLFGVRL KRAPPSQKYK SEKQDNFTQL
  1501  ASVPSGPISS SVGRGHKIRS TSQGLLDAAG NLTKISYVAD KQQSRPKSES MAKKQPACKT
  1561  PGKPAGQQSD YAVSEPVWIT MAKQKQKSFK AHISVKELKT KSNAGADAET KEPKYEGAGS
  1621  ANENQPKKMF TSSVHKQEKT AQMKPPKPTK SVGFEAQKIL QVPAMEKETK RSSTLPAKFQ
  1681  NPVEPIEPVW FSLARKKAKA WSHMAEITQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KIAA1210 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.7
Highest tissue expression: 39 nTPM

Expression across tissuesHPA

Tissue

epididymis: 39 nTPM
testis: 31 nTPM
seminal vesicle: 20 nTPM
fallopian tube: 5 nTPM
prostate: 4.7 nTPM
endometrium: 1.6 nTPM

Single-cell type

sertoli cells: 219 nCPM
endometrial stromal cells: 27 nCPM
fibroblasts: 16 nCPM
late spermatids: 14 nCPM
smooth muscle cells: 8.8 nCPM
early spermatids: 5.9 nCPM

Immune cell

basophil: 0.4 nTPM
neutrophil: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

cerebral cortex: 0.6 nTPM
cerebellum: 0.5 nTPM
choroid plexus: 0.5 nTPM
white matter: 0.5 nTPM
amygdala: 0.4 nTPM
basal ganglia: 0.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.45
gnomAD pLI: 0.01
gnomAD missense Z: -0.24
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

acrosomal vesicle

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Cytoplasmic vesicle

InteractionsUniProt · HPA

Protein binding partners of KIAA1210 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TOP2B

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KIAA1210 as an antibody target. Whether an autoantibody or antibody against KIAA1210 could matter depends on whether native KIAA1210 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KIAA1210 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KIAA1210 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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