KIAA1143
Uncharacterized protein KIAA1143
Also known as: K1143_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q96AT1
- Gene
- KIAA1143
- Ensembl
- ENSG00000163807
- Chromosome
- 3
- Canonical length
- 154 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Cytokinetic bridge
OverviewNCBI Gene
No narrative summary is available for KIAA1143 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
154 residues, UniProt reviewed canonical sequence.
>Q96AT1|KIAA1143
1 MSKRNQVSYV RPAEPAFLAR FKERVGYREG PTVETKRIQP QPPDEDGDHS DKEDEQPQVV
61 VLKKGDLSVE EVMKIKAEIK AAKADEEPTP ADGRIIYRKP VKHPSDEKYS GLTASSKKKK
121 PNEDEVNQDS VKKNSQKQIK NSSLLSFDNE DENELocalizationUniProt · AlphaFold · HPA
Whether an antibody against KIAA1143 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.63
- Highest tissue expression
- 17 nTPM
Expression across tissuesHPA
Tissue
- skeletal muscle: 17 nTPM
- spinal cord: 11 nTPM
- midbrain: 11 nTPM
- ovary: 11 nTPM
- endometrium: 9.8 nTPM
- heart muscle: 9.3 nTPM
Single-cell type
- early spermatids: 199 nCPM
- late primary spermatocytes: 82 nCPM
- late spermatids: 66 nCPM
- bergmann glia: 15 nCPM
- epididymal efferent duct absorptive cells: 14 nCPM
- oligodendrocytes: 14 nCPM
Immune cell
- eosinophil: 4 nTPM
- non-classical monocyte: 3.9 nTPM
- NK-cell: 3 nTPM
- gdT-cell: 2.8 nTPM
- basophil: 2.6 nTPM
- intermediate monocyte: 2.5 nTPM
Brain region
- white matter: 16 nTPM
- pons: 13 nTPM
- medulla oblongata: 13 nTPM
- basal ganglia: 13 nTPM
- midbrain: 13 nTPM
- thalamus: 12 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.32
- gnomAD pLI
- 0.01
- gnomAD missense Z
- -0.04
- DepMap mean gene effect
- -0.34
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
- Domain of unknown function DUF4604
- Uncharacterized protein KIAA1143-like
- Domain of unknown function (DUF4604)
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of KIAA1143 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads KIAA1143 as an antibody target. Whether an autoantibody or antibody against KIAA1143 could matter depends on whether native KIAA1143 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
KIAA1143 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label KIAA1143 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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