Seroatlas · Human Serome Atlas

KIAA0825

Uncharacterized protein KIAA0825

Also known as: C5orf36, DKFZp686F0372, K0825_HUMAN, MGC34713

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8IV33
Gene
KIAA0825
Ensembl
ENSG00000185261
Chromosome
5
Canonical length
1275 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for KIAA0825 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

1275 residues, UniProt reviewed canonical sequence.

>Q8IV33|KIAA0825
     1  MDWDDEYSHN SFDLHCLLNS FPGDLEFEQI FSDIDEKIEQ NAASIKHCIK EIQSEINKQC
    61  PGVQLQTTTD CFEWLTNYNY STSESSFISH GDLIKFFKTL QDLLKNEQNQ EEMTLDLLWD
   121  LSCHSSVSFP STLSGTSFHF LSRTSLHSVE DNSSMDVKSM WDDIRLHLRR FLVSKLQSHN
   181  EINNSQQKIL LKKQCLQQLL FLYPESEVII KYQNIQNKLL ANLLWNCFPS YNRDSNLDVI
   241  AHGYQSTMLK LYSVIKEDFN TLCEILAPSS MVKFIKETYL DTVTEEMAKF LENFCELQFR
   301  ENAVRVVKTS KSSSKHRGAV HALVTTECPQ KGRNFSLPLD KVEFLSQLIK SFMKLEKGVQ
   361  ELFDEILLSL KITRDTSGIL EKSDREVVME KPRANETNIP SEQSLPGKEA TLLDFGWRSA
   421  FKEVSLPMAH CVVTAIEGFS TKILQQEQNE RSSAVSYAMN LVNVQQVWQD SHMFPEEEQP
   481  KKIGKFCSDI MEKLDTMLPL ALACRDDSFQ EIRANLVEAC CKVATAVLQR LQERAKEVPS
   541  KAPLKNLHTY LSTAVYVFQH FKRYDNLMKE MTKKPIFLVL VQRYQEFINT LQFQVTNYCV
   601  RVCATSILQD AESHHWDDYK AFYEGERCSF SIQMWHYFCW SLHYDLWTIL PPKLAQEILV
   661  EVLEKSLSLL ASRYARAHPS RKRTPQLRLD VTTILICTEN MLWSVCTSVQ KLLNPHQHTD
   721  DKIFKIHTHC NNLFTTLVIL TSPLTELYKT FQHGLDESAS DSLKSFFKQP LYWVSCISHF
   781  YPSLLRTPSA GGLKAEGQLK LLLSQPRCNW NLLLETLLHH DGLLLRILLK SSKQVSDTEN
   841  NLNQGPSLME AIFKILYHCS FSPQTFANVF VSYMEEEQLW DFLYNIPVST CVEYELEVIR
   901  CLRLALTDAI KDTVQQIVSV MSSRRNCETN LNKHIVPDCL LESMPKEWNY SPKETNRKES
   961  CKSFTRLTAQ AVSIVISKLP TVIACLPPPV KYFFFLSERK MSKKFVELKK AGLLVWNLIV
  1021  IICRIFEDGN TVELLTGASL DRWSKEKLGL ICMCLKSIMG DQTSIHNQMI QKVIQSIEQQ
  1081  KPNWIERQLL KARKLSTECA FMTIEKSTAL QEGDVALELT EQKINTMVLD LCHKPGGREY
  1141  LRQIYHIMQL NEEYLKEQLF SMNSSEEKPL PIRPLKTTLR SIEDQPSAFN PFHVYKAFSE
  1201  NMLDQSAITK WNWNWAKLLP NYLRLDKMTF SVLLKNRWEM KKDETLEEEE KAILEHLKQI
  1261  CTPQNSSASD NIEEQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KIAA0825 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
3.1 nTPM

Expression across tissuesHPA

Tissue

  • retina: 3.1 nTPM
  • testis: 2.6 nTPM
  • fallopian tube: 2.2 nTPM
  • thyroid gland: 1.7 nTPM
  • cerebral cortex: 1.5 nTPM
  • basal ganglia: 1.4 nTPM

Single-cell type

  • neutrophils: 2,010 nCPM
  • ependymal cells: 1,263 nCPM
  • respiratory ciliated cells: 825 nCPM
  • cone photoreceptor cells: 613 nCPM
  • neutrophil progenitors: 475 nCPM
  • lactotrophs: 448 nCPM

Immune cell

  • neutrophil: 12 nTPM
  • basophil: 1.9 nTPM
  • memory B-cell: 0.9 nTPM
  • NK-cell: 0.9 nTPM
  • non-classical monocyte: 0.8 nTPM
  • memory CD8 T-cell: 0.7 nTPM

Brain region

  • cerebral cortex: 9.9 nTPM
  • medulla oblongata: 9.9 nTPM
  • midbrain: 9.6 nTPM
  • basal ganglia: 9.4 nTPM
  • cerebellum: 9.4 nTPM
  • thalamus: 8.9 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about KIAA0825.

Disease | AllUniProt

Conditions KIAA0825 is implicated in, by any mechanism.

Disease | GeneticClinVar

11 pathogenic / likely-pathogenic of 97 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.53
gnomAD pLI
0
gnomAD missense Z
0.59
DepMap mean gene effect
-0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

  • Protein of unknown function DUF4495
  • Domain of unknown function (DUF4495)

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KIAA0825 as an antibody target. Whether an autoantibody or antibody against KIAA0825 could matter depends on whether native KIAA0825 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KIAA0825 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KIAA0825 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KIAA0825. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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