Seroatlas · Human Serome Atlas

KIAA0513

Uncharacterized protein KIAA0513

Also known as: K0513_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O60268
Gene: KIAA0513
Ensembl: ENSG00000135709
Chromosome: 16
Canonical length: 411 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

411 residues, UniProt reviewed canonical sequence.

>O60268|KIAA0513
     1  METPEVPVGS LIDFGPEAPT SSPLEAPPPV LQDGDGSLGD GASESETTES ADSENDMGES
    61  PSHPSWDQDR RSSSNESFSS NQSTESTQDE ETLALRDFMR GYVEKIFSGG EDLDQEEKAK
   121  FGEYCSSENG KGREWFARYV SAQRCNSKCV SEATFYRLVQ SFAVVLFECH QMDDFGPAKN
   181  LMTMCFTYYH IGKPQLLPPE SREKPAGSID SYLKSANSWL AEKKDIAERL LKNTSARTEN
   241  VKGFFGGLET KLKGPLARRN EEDENKPQEK RPRAVTAYSP EDEKKGEKIY LYTHLKQQPI
   301  WHTLRFWNAA FFDAVHCERT KRSPTTRGDA GEEEEKREKW CHMTQEERDD SLRFNENITF
   361  GQLGTFTHNM LAFGLNKKLC NDFLKKQAVI GNLDEEQYKL LSDHIEQMAT E

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KIAA0513 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 54 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 54 nTPM
cerebellum: 49 nTPM
pituitary gland: 29 nTPM
amygdala: 27 nTPM
basal ganglia: 27 nTPM
hippocampal formation: 26 nTPM

Single-cell type

late spermatids: 456 nCPM
platelets: 401 nCPM
somatotrophs: 176 nCPM
lactotrophs: 142 nCPM
neutrophils: 134 nCPM
neutrophil progenitors: 120 nCPM

Immune cell

basophil: 25 nTPM
non-classical monocyte: 24 nTPM
neutrophil: 19 nTPM
eosinophil: 13 nTPM
intermediate monocyte: 13 nTPM
classical monocyte: 11 nTPM

Brain region

cerebral cortex: 236 nTPM
cerebellum: 176 nTPM
hippocampal formation: 170 nTPM
white matter: 159 nTPM
basal ganglia: 153 nTPM
amygdala: 142 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.48
gnomAD pLI: 0.23
gnomAD missense Z: -0.29
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

Uncharacterized protein KIAA0513

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KIAA0513 as an antibody target. Whether an autoantibody or antibody against KIAA0513 could matter depends on whether native KIAA0513 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KIAA0513 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KIAA0513 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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