Seroatlas · Human Serome Atlas

KIAA0040

Uncharacterized protein KIAA0040

Also known as: K0040_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q15053
Gene
KIAA0040
Ensembl
ENSG00000235750
Chromosome
1
Canonical length
99 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

99 residues, UniProt reviewed canonical sequence.

>Q15053|KIAA0040
     1  MERISAFFSS IWDTILTKHQ EGIYNTICLG VLLGLPLLVI ITLLFICCHC CWSPPGKRGQ
    61  QPEKNKKKKK KKKKKDEEDL WISAQPKLLQ MEKRPSLPV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KIAA0040 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.57
Highest tissue expression
94 nTPM

Expression across tissuesHPA

Tissue

  • placenta: 94 nTPM
  • adipose tissue: 42 nTPM
  • lung: 38 nTPM
  • tonsil: 30 nTPM
  • lymph node: 28 nTPM
  • spleen: 25 nTPM

Single-cell type

  • syncytiotrophoblasts: 586 nCPM
  • neutrophils: 343 nCPM
  • thymic myoid cells: 212 nCPM
  • epididymal basal cells: 159 nCPM
  • salivary acinar cells: 145 nCPM
  • epididymal efferent duct ciliated cells: 140 nCPM

Immune cell

  • neutrophil: 51 nTPM
  • basophil: 32 nTPM
  • memory B-cell: 29 nTPM
  • naive B-cell: 28 nTPM
  • T-reg: 19 nTPM
  • classical monocyte: 12 nTPM

Brain region

  • medulla oblongata: 11 nTPM
  • choroid plexus: 7.7 nTPM
  • pons: 7.5 nTPM
  • midbrain: 5.9 nTPM
  • spinal cord: 5.3 nTPM
  • thalamus: 5.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.53
gnomAD pLI
0.2
gnomAD missense Z
1.03

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Uncharacterized protein KIAA0040-like

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KIAA0040 as an antibody target. Whether an autoantibody or antibody against KIAA0040 could matter depends on whether native KIAA0040 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KIAA0040 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KIAA0040 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KIAA0040. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...