KGD4

Protein identityUniProt · HPA

UniProt accession

P82909

Gene

KGD4

Ensembl

ENSG00000134056

Chromosome

5

Canonical length

103 aa

Protein class

Predicted intracellular proteins

Subcellular location

Mitochondria

OverviewNCBI Gene

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. The mitochondrial ribosome (mitoribosome) consists of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. Pseudogenes corresponding to this gene are found on chromosomes 3p, 4q, 8p, 11q, 12q, and 20p. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

103 residues, UniProt reviewed canonical sequence.

>P82909|KGD4
     1  MMGSKMASAS RVVQVVKPHT PLIRFPDRRD NPKPNVSEAL RSAGLPSHSS VISQHSKGSK
    61  SPDLLMYQGP PDTAEIIKTL PQKYRRKLVS QEEMEFIQRG GPE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KGD4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.64

Highest tissue expression

63 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about KGD4.

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 19 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Leigh syndrome

Disease | ImmuneIEDB

Conditions an epitope on KGD4 was assayed in.

• narcolepsy B cell
• multiple sclerosis B cell
• peripheral nervous system disease B cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.23

gnomAD pLI

0.11

DepMap mean gene effect

-0.17

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• 2-oxoglutarate metabolic process
• tricarboxylic acid cycle

Molecular functions

• protein-macromolecule adaptor activity

Cellular components

• mitochondrial inner membrane
• mitochondrion
• oxoglutarate dehydrogenase complex

Protein domainsUniProt · Pfam · InterPro

• Alpha-ketoglutarate dehydrogenase component 4/YMR-31

KeywordsUniProt

• Acetylation
• Mitochondrion
• Phosphoprotein
• Tricarboxylic acid cycle

InteractionsUniProt · HPA

Protein binding partners of KGD4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• DLD