Seroatlas · Human Serome Atlas

KDM4F

Probable lysine-specific demethylase 4F

Also known as: KDM4F_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A0A1W2PPD8
Gene: KDM4F
Canonical length: 638 aa
Protein class: Enzymes, Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for KDM4F in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

638 residues, UniProt reviewed canonical sequence.

>A0A1W2PPD8|KDM4F
     1  MKSVHSSPQN TSHTIMTFYP TMEEFADFNT YVAYMESQGA HRAGLAKVIP PKEWKARQMY
    61  DDIEDILIAT PLQQVTSGQG GVFTQYHKKK KAMRVGQYRH LANSKKYQTP PHQNFADLEQ
   121  RYWKSHPGNP PIYGADISGS LFEESTKQWN LGHLGTILDL LEQECGVVIE GVNTPYLYFG
   181  MWKTTFAWHT EDMDLYSINY LHFGEPKTWY VVPPEHGQRL ECLARELFPG NSRGCEGFLR
   241  HKVALISPTV LKKNGIPFNR MTQEAGEFMV TFPYGYHAGF NHGFNCAEAI NFATPRWIDY
   301  GKVASQCSCG EARVTFSMDA FVRILQPESY ELWKHRQDLT VVDYMEPRVA ESQEPSNWRE
   361  DIALRRAALG LRHLRNHITS CPTRTVAPRL CYNPKGGGTD AVPGSAIQAL ETSAWVLPPS
   421  TGRWGPCRGC GRGRGRGRGR GRRPRELGTE ETTVQSAAKR RLSVGTGSRA PGRKPQLQFA
   481  DEALTDKPAP LSGGLPHFAK ASGCCCAPDL QPLGPPLDPD EPMHPGPCLL SLDSTASSLP
   541  LVVPMTPPSV TVPLITLSRD TGGDWKSPVN LAKVVAMDHS YASRVPVPTK FSRISWAPDS
   601  SAGAKARQRY ATEFGDIFLQ CMINPLDPWP LNMVSNVK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KDM4F can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 0 nTPM

Expression across tissuesHPA

Tissue

adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM
blood vessel: 0 nTPM

Single-cell type

adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM
alveolar cells type 1: 0 nCPM
alveolar cells type 2: 0 nCPM
astrocytes: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

midbrain: 0.1 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KDM4F as an antibody target. Whether an autoantibody or antibody against KDM4F could matter depends on whether native KDM4F is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KDM4F is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KDM4F as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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