Seroatlas · Human Serome Atlas

KDM4E

Lysine-specific demethylase 4E

Also known as: JMJD2E, KDM4DL, KDM4E_HUMAN, KDM5E

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: B2RXH2
Gene: KDM4E
Ensembl: ENSG00000235268
Chromosome: 11
Canonical length: 506 aa
Protein class: Enzymes, Predicted intracellular proteins

OverviewNCBI Gene

The protein encoded by this intronless gene is a member of a large family of histone lysine demethylases, which use oxygen and 2-oxoglutarate to demethylate di- and trimethylated lys9 of histone H3. Derepression of genes by demethylases is sometimes involved in viral infection or carcinogenesis, so inhibitors of these enzymes are desired. [provided by RefSeq, Dec 2016]

Canonical amino-acid sequenceUniProt

506 residues, UniProt reviewed canonical sequence.

>B2RXH2|KDM4E
     1  MKSVHSSPQN TSHTIMTFYP TMEEFADFNT YVAYMESQGA HQAGLAKVIP PKEWKARQMY
    61  DDIEDILIAT PLQQVTSGQG GVFTQYHKKK KAMRVGQYRR LANSKKYQTP PHQNFADLEQ
   121  RYWKSHPGNP PIYGADISGS LFEESTKQWN LGHLGTILDL LEQECGVVIE GVNTPYLYFG
   181  MWKTTFAWHT EDMDLYSINY LHFGEPKTWY VVPPEHGQHL ERLARELFPD ISRGCEAFLR
   241  HKVALISPTV LKENGIPFNC MTQEAGEFMV TFPYGYHAGF NHGFNCAEAI NFATPRWIDY
   301  GKMASQCSCG ESTVTFSMDP FVRIVQPESY ELWKHRQDLA IVEHTEPRVA ESQELSNWRD
   361  DIVLRRAALG LRLLPNLTAQ CPTQPVSSGH CYNPKGCGTD AVPGSAFQSS AYHTQTQSLT
   421  LGMSARVLLP STGSWGSGRG RGRGQGQGRG CSRGRGHGCC TRELGTEEPT VQPASKRRLL
   481  MGTRSRAQGH RPQLPLANDL MTNLSL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KDM4E can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 0.3 nTPM

Expression across tissuesHPA

Tissue

testis: 0.3 nTPM
salivary gland: 0.2 nTPM
skin: 0.2 nTPM
pituitary gland: 0.1 nTPM
prostate: 0.1 nTPM
spleen: 0.1 nTPM

Single-cell type

adipocytes: 0.9 nCPM
vascular endothelial cells: 0.2 nCPM
cardiomyocytes: 0.1 nCPM
fibroblasts: 0.1 nCPM
gonadotrophs: 0.1 nCPM
pericytes: 0.1 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

medulla oblongata: 0.4 nTPM
pons: 0.4 nTPM
amygdala: 0.3 nTPM
hypothalamus: 0.3 nTPM
spinal cord: 0.3 nTPM
thalamus: 0.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.33
gnomAD pLI: 0.51
gnomAD missense Z: 0.17
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KDM4E as an antibody target. Whether an autoantibody or antibody against KDM4E could matter depends on whether native KDM4E is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KDM4E is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KDM4E as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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