Seroatlas · Human Serome Atlas

KCT2

Keratinocyte-associated transmembrane protein 2

Also known as: C5orf15, HTGN29, KCT2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NC54
Gene: KCT2
Ensembl: ENSG00000113583
Chromosome: 5
Canonical length: 265 aa
Protein class: Predicted membrane proteins
Subcellular location: Golgi apparatus

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

265 residues, UniProt reviewed canonical sequence.

>Q8NC54|KCT2
     1  MAAAVPKRMR GPAQAKLLPG SAIQALVGLA RPLVLALLLV SAALSSVVSR TDSPSPTVLN
    61  SHISTPNVNA LTHENQTKPS ISQISTTLPP TTSTKKSGGA SVVPHPSPTP LSQEEADNNE
   121  DPSIEEEDLL MLNSSPSTAK DTLDNGDYGE PDYDWTTGPR DDDESDDTLE ENRGYMEIEQ
   181  SVKSFKMPSS NIEEEDSHFF FHLIIFAFCI AVVYITYHNK RKIFLLVQSR KWRDGLCSKT
   241  VEYHRLDQNV NEAMPSLKIT NDYIF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KCT2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.66
Highest tissue expression: 75 nTPM

Expression across tissuesHPA

Tissue

liver: 75 nTPM
kidney: 69 nTPM
placenta: 55 nTPM
thyroid gland: 50 nTPM
adrenal gland: 47 nTPM
ovary: 47 nTPM

Single-cell type

fallopian tube ciliated cells: 150 nCPM
respiratory ciliated cells: 127 nCPM
cytotrophoblasts: 98 nCPM
melanocytes: 98 nCPM
extravillous trophoblasts: 95 nCPM
endometrial ciliated cells: 90 nCPM

Immune cell

myeloid DC: 37 nTPM
intermediate monocyte: 35 nTPM
non-classical monocyte: 34 nTPM
classical monocyte: 32 nTPM
total PBMC: 29 nTPM
plasmacytoid DC: 27 nTPM

Brain region

choroid plexus: 36 nTPM
white matter: 27 nTPM
spinal cord: 20 nTPM
medulla oblongata: 19 nTPM
hypothalamus: 19 nTPM
midbrain: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.08
gnomAD pLI: 0.05
DepMap mean gene effect: -0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

Keratinocyte-associated gene product
Keratinocyte-associated transmembrane protein 2

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KCT2 as an antibody target. Whether an autoantibody or antibody against KCT2 could matter depends on whether native KCT2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KCT2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KCT2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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