Seroatlas · Human Serome Atlas

KCP

Kielin/chordin-like protein

Also known as: CRIM2, FLJ33365, KCP_HUMAN, NET67

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZWJ8
Gene: KCP
Ensembl: ENSG00000135253
Chromosome: 7
Canonical length: 1568 aa
Protein class: Predicted secreted proteins
Secretome location: Secreted in other tissues

OverviewNCBI Gene

Predicted to be involved in positive regulation of BMP signaling pathway. Predicted to act upstream of or within hematopoietic progenitor cell differentiation. Predicted to be located in extracellular space. Predicted to be active in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1568 residues, UniProt reviewed canonical sequence.

>Q6ZWJ8|KCP
     1  MAGVGAAALS LLLHLGALAL AAGAEGGAVP REPPGQQTTA HSSVLAGNSQ EQWHPLREWL
    61  GRLEAAVMEL REQNKDLQTR VRQLESCECH PASPQCWGLG RAWPEGARWE PDACTACVCQ
   121  DGAAHCGPQA HLPHCRGCSQ NGQTYGNGET FSPDACTTCR CLTGAVQCQG PSCSELNCLE
   181  SCTPPGECCP ICRPGCDYEG QLYEEGVTFL SSSNPCLQCT CLRSRVRCMA LKCPPSPCPE
   241  PVLRPGHCCP TCQGCTEGGS HWEHGQEWTT PGDPCRICRC LEGHIQCRQR ECASLCPYPA
   301  RPLPGTCCPV CDGCFLNGRE HRSGEPVGSG DPCSHCRCAN GSVQCEPLPC PPVPCRHPGK
   361  IPGQCCPVCD GCEYQGHQYQ SQETFRLQER GLCVRCSCQA GEVSCEEQEC PVTPCALPAS
   421  GRQLCPACEL DGEEFAEGVQ WEPDGRPCTA CVCQDGVPKC GAVLCPPAPC QHPTQPPGAC
   481  CPSCDSCTYH SQVYANGQNF TDADSPCHAC HCQDGTVTCS LVDCPPTTCA RPQSGPGQCC
   541  PRCPDCILEE EVFVDGESFS HPRDPCQECR CQEGHAHCQP RPCPRAPCAH PLPGTCCPND
   601  CSGCAFGGKE YPSGADFPHP SDPCRLCRCL SGNVQCLARR CVPLPCPEPV LLPGECCPQC
   661  PAAPAPAGCP RPGAAHARHQ EYFSPPGDPC RRCLCLDGSV SCQRLPCPPA PCAHPRQGPC
   721  CPSCDGCLYQ GKEFASGERF PSPTAACHLC LCWEGSVSCE PKACAPALCP FPARGDCCPD
   781  CDGCEYLGES YLSNQEFPDP REPCNLCTCL GGFVTCGRRP CEPPGCSHPL IPSGHCCPTC
   841  QGCRYHGVTT ASGETLPDPL DPTCSLCTCQ EGSMRCQKKP CPPALCPHPS PGPCFCPVCH
   901  SCLSQGREHQ DGEEFEGPAG SCEWCRCQAG QVSCVRLQCP PLPCKLQVTE RGSCCPRCRG
   961  CLAHGEEHPE GSRWVPPDSA CSSCVCHEGV VTCARIQCIS SCAQPRQGPH DCCPQCSDCE
  1021  HEGRKYEPGE SFQPGADPCE VCICEPQPEG PPSLRCHRRQ CPSLVGCPPS QLLPPGPQHC
  1081  CPTCAEALSN CSEGLLGSEL APPDPCYTCQ CQDLTWLCIH QACPELSCPL SERHTPPGSC
  1141  CPVCRAPTQS CVHQGREVAS GERWTVDTCT SCSCMAGTVR CQSQRCSPLS CGPDKAPALS
  1201  PGSCCPRCLP RPASCMAFGD PHYRTFDGRL LHFQGSCSYV LAKDCHSGDF SVHVTNDDRG
  1261  RSGVAWTQEV AVLLGDMAVR LLQDGAVTVD GHPVALPFLQ EPLLYVELRG HTVILHAQPG
  1321  LQVLWDGQSQ VEVSVPGSYQ GRTCGLCGNF NGFAQDDLQG PEGLLLPSEA AFGNSWQVSE
  1381  GLWPGRPCSA GREVDPCRAA GYRARREANA RCGVLKSSPF SRCHAVVPPE PFFAACVYDL
  1441  CACGPGSSAD ACLCDALEAY ASHCRQAGVT PTWRGPTLCV VGCPLERGFV FDECGPPCPR
  1501  TCFNQHIPLG ELAAHCVRPC VPGCQCPAGL VEHEAHCIPP EACPQVLLTG DQPLGARPSP
  1561  SREPQETP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KCP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 18 nTPM

Expression across tissuesHPA

Tissue

kidney: 18 nTPM
seminal vesicle: 2 nTPM
esophagus: 1.5 nTPM
adipose tissue: 1.3 nTPM
cervix: 1.1 nTPM
gallbladder: 0.9 nTPM

Single-cell type

renal collecting duct principal cells: 149 nCPM
cardiomyocytes: 140 nCPM
loop of henle epithelial cells: 105 nCPM
papillary tip epithelial cells: 101 nCPM
epicardial cells: 86 nCPM
enterocytes: 66 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 3.8 nTPM
thalamus: 0.9 nTPM
pons: 0.3 nTPM
cerebral cortex: 0.2 nTPM
hypothalamus: 0.2 nTPM
amygdala: 0.1 nTPM

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

positive regulation of BMP signaling pathway

Cellular components

extracellular region

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KCP as an antibody target. Whether an autoantibody or antibody against KCP could matter depends on whether native KCP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KCP is annotated as secreted, so native KCP circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label KCP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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