Seroatlas · Human Serome Atlas

KCNQ1DN

KCNQ1 downstream neighbor protein

Also known as: KCQ1D_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H478
Gene: KCNQ1DN
Canonical length: 68 aa

OverviewNCBI Gene

No narrative summary is available for KCNQ1DN in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

68 residues, UniProt reviewed canonical sequence.

>Q9H478|KCNQ1DN
     1  MGRKWSGPTA EHQLPMPPPG VRLDSWKGVA SGCSPSKASQ EARGKEKCPT LNGQPQWSAL
    61  FTLPPQRE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KCNQ1DN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.67

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KCNQ1DN as an antibody target. Whether an autoantibody or antibody against KCNQ1DN could matter depends on whether native KCNQ1DN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KCNQ1DN is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KCNQ1DN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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