Seroatlas · Human Serome Atlas

KCNMB2

Calcium-activated potassium channel subunit beta-2

Also known as: KCMB2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y691
Gene
KCNMB2
Ensembl
ENSG00000197584
Chromosome
3
Canonical length
235 aa
Protein class
FDA approved drug targets, Predicted membrane proteins, Transporters

OverviewNCBI Gene

MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which decreases the activation time of MaxiK alpha subunit currents. Alternative splicing results in multiple transcript variants of this gene. Additional variants are discussed in the literature, but their full length nature has not been described. [provided by RefSeq, Jul 2013]

Canonical amino-acid sequenceUniProt

235 residues, UniProt reviewed canonical sequence.

>Q9Y691|KCNMB2
     1  MFIWTSGRTS SSYRHDEKRN IYQKIRDHDL LDKRKTVTAL KAGEDRAILL GLAMMVCSIM
    61  MYFLLGITLL RSYMQSVWTE ESQCTLLNAS ITETFNCSFS CGPDCWKLSQ YPCLQVYVNL
   121  TSSGEKLLLY HTEETIKINQ KCSYIPKCGK NFEESMSLVN VVMENFRKYQ HFSCYSDPEG
   181  NQKSVILTKL YSSNVLFHSL FWPTCMMAGG VAIVAMVKLT QYLSLLCERI QRINR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KCNMB2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
2
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
33 nTPM

Expression across tissuesHPA

Tissue

  • epididymis: 33 nTPM
  • fallopian tube: 13 nTPM
  • ovary: 10 nTPM
  • heart muscle: 5.4 nTPM
  • adrenal gland: 4.8 nTPM
  • hippocampal formation: 4.5 nTPM

Single-cell type

  • oligodendrocyte progenitor cells: 2,626 nCPM
  • ependymal cells: 1,529 nCPM
  • epicardial cells: 357 nCPM
  • brain inhibitory neurons: 321 nCPM
  • brain excitatory neurons: 279 nCPM
  • cardiomyocytes: 162 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 8 nTPM
  • hippocampal formation: 8 nTPM
  • medulla oblongata: 6.2 nTPM
  • midbrain: 5.4 nTPM
  • basal ganglia: 5.1 nTPM
  • amygdala: 4.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.57
gnomAD pLI
0.55
gnomAD missense Z
0.86
DepMap mean gene effect
0.22
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KCNMB2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KCNMB2 as an antibody target. Whether an autoantibody or antibody against KCNMB2 could matter depends on whether native KCNMB2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KCNMB2 is annotated at the cell surface, where native KCNMB2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label KCNMB2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KCNMB2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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