Seroatlas · Human Serome Atlas

KCNMB1

Calcium-activated potassium channel subunit beta-1

Also known as: hslo-beta, KCMB1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q16558
Gene: KCNMB1
Ensembl: ENSG00000145936
Chromosome: 5
Canonical length: 191 aa
Protein class: FDA approved drug targets, Predicted membrane proteins, Transporters

OverviewNCBI Gene

MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the product of this gene, the modulatory beta subunit. Intracellular calcium regulates the physical association between the alpha and beta subunits. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

191 residues, UniProt reviewed canonical sequence.

>Q16558|KCNMB1
     1  MVKKLVMAQK RGETRALCLG VTMVVCAVIT YYILVTTVLP LYQKSVWTQE SKCHLIETNI
    61  RDQEELKGKK VPQYPCLWVN VSAAGRWAVL YHTEDTRDQN QQCSYIPGSV DNYQTARADV
   121  EKVRAKFQEQ QVFYCFSAPR GNETSVLFQR LYGPQALLFS LFWPTFLLTG GLLIIAMVKS
   181  NQYLSILAAQ K

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KCNMB1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 76 nTPM

Expression across tissuesHPA

Tissue

colon: 76 nTPM
blood vessel: 70 nTPM
endometrium: 57 nTPM
smooth muscle: 50 nTPM
seminal vesicle: 48 nTPM
urinary bladder: 38 nTPM

Single-cell type

peritubular myoid cells: 344 nCPM
smooth muscle cells: 229 nCPM
breast myoepithelial cells: 166 nCPM
decidual stromal cells: 164 nCPM
microglia: 138 nCPM
vascular smooth muscle cells: 116 nCPM

Immune cell

intermediate monocyte: 5.9 nTPM
myeloid DC: 5.7 nTPM
non-classical monocyte: 5 nTPM
classical monocyte: 3.3 nTPM
plasmacytoid DC: 2 nTPM
basophil: 1.3 nTPM

Brain region

pons: 19 nTPM
medulla oblongata: 18 nTPM
midbrain: 15 nTPM
thalamus: 15 nTPM
white matter: 15 nTPM
spinal cord: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.6
gnomAD pLI: 0
gnomAD missense Z: 0.22
DepMap mean gene effect: 0.23
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KCNMB1 as an antibody target. Whether an autoantibody or antibody against KCNMB1 could matter depends on whether native KCNMB1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KCNMB1 is annotated at the cell surface, where native KCNMB1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label KCNMB1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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